Copper Catalyzed Oxidative Amination Of Alkenes

Nitrogen-containing compounds exist widely in natural products and synthetic molecules,and are used in chemical,pharmaceutical and materials fields.Therefore,the development of C–N bond formation is an important research area in organic synthesis chemistry.Over the years,a variety of C–N bond formation,including traditional nucleophilic substitution,nitrogen reduction,alkylation of imines and reduction amination reaction was achieved.In recent years,the transition-metal-catalyzed C–N bond formation reactions,such as Buchwald-Hartwig C–N coupling,hydroamination and diamine of olefins,allylic amination reaction are emerging.Obviously,the construction of the C–N bond directly from the C–H bond is the most straightforward and consists with the green chemistry.Therefore,the development of direct amination of the C–H bond is very appealing.Enamine is a kind of important nitrogen-containing compounds,and used as organic synthetic intermediates.It is necessary to develop a simple and efficient method for the synthesis of enamine derivatives.If enamines could be synthesized through direct C–H bond amination of readily available olefins,it should be very attractive.At present,Pd-catalyzed oxidative amination of olefins has been widely reported.In contrast,Cu-catalyzed reactions are less.In this thesis,Cu-catalyzed high regioselective oxidative amination of styrene derivatives and diphenyl sulfimide was realized,producing a series of enamine derivatives.This method was simple and easy to operate,which provided a new choice for the synthesis of enamine derivatives.