Study On The Preparation And Reaction Of Monofluoroalkylphosphonium Salt

Objective:The incorporation of fluorine-containing functional groups could significantly modify the physical and biological properties of molecules,in order to introduce monofluoroaklyl group into carbonyl compounds and imines,we envisioned to design and synthesize monofluoroalkyl phosphonium salt and explore its nucleophilic addition reactions.Methods:We used the quaternization of Ph₃P with BrCFHCO₂Et,and with the methylation reaction of product,finally obtain the target product monofluoromethyl phosphonium salt.Results:We synthetize momofluorinated phosphonium salt,and complished the nucleophilic addition reactions of aldehydes,ketones and imines compounds.The chemical structures of the new compounds were determined by ¹H NMR,¹⁹F NMR,¹³C NMR,IR,MS and melting point,and the configuration of these three compounds was determined by X-ray crystal diffraction.