Diethyl Phosphate Promoted Dehydroxylation Of Magnesium And Praseodymium Grignard Reagents With Carbonyl Compounds

This thesis consists of the following two sections:1.The reaction of magnesium Grignard reagent with aldehydes and ketones in the presence of diphenyl phosphate affords Diphenylmethane compoundsDiphenylmethane compounds are presenting the structures of a wide variety of natural products that exhibit various biological properties.In addition,Diphenylmethanes are useful building blocks for the synthesis of organic.Based on our previous work,we use simple carbonyl compounds as substrate,then add diethyl phosphate to promote this reaction to afford the target products.These systems have significant advantages:(1)Substrates of aldehydes are cheap and easy to get;(2)The reaction can realize one-pot synthesis of diphenylmethane;(3)The reaction has simple operation and mild conditions,the maximum yield can reach 95%.2.Praseodymium promoted carbonyl olefination in the presence of diethyl phosphateThe Barbier reactions of allylic halides such as 3-bromoprop-1-ene,3-iodoprop-1-ene,1-bromo-3-methylbut-2-ene,1-chloro-3-methylbut-2-ene,3-bromo-2-methylprop-1-ene,(E)-(3-bromoprop-1-en-1-yl)benzene with aldehydes or ketones promoted by praseodymium in the precence of diethyl phosphate afford the corresponding olefines.This reaction was conveniently carried out under mild conditions in a one-pot fashion with moderate to good yields.