The Study Of Electrosynthesis Of ?-iodoazides And Acyl Azides

Organic azide compound is an important class of organic compounds.Azide functional group as a pharmaceutically active group,in the anti-virus,anti-bacterial,etc.has a wide range of applications.Organic azide compound can be transformed into triazole,tetrazole,aziridine,amine compounds after derivations.With the development of research methods,azide derivatives as fundamental blocks can be use at medicine field and biological engineering field.In addition,azide group has excellent potential applications in material science.The chemical property of azo functional group was lively,prone to explosion.Therefore,the designs of conditions are mild,the steps are simple,and the way of environmental protection of synthetic azide compound is of great significance.In this paper,the synthetic methods of organic azide compound were reviewed,and a new method for synthesizing two kinds of different azide compounds by electrochemical means is presented.The ?-iodoazide organic compound has both azide functional groups and halogen groups,which can further prepare alkenyl azide compounds or further derivatized as other ortho-substituted nitrogen-containing compounds.The first part of the work in this paper was performed in the divided electrolytic cell,olefin compounds as a substrate,having an addition reaction with sodium iodide and sodium azide.After a variety of reaction conditions were tried,a series of substrates were investigated for the universality.Through the analysis of the structure of the product,it was found that it was the Markov regular addition product,which determined the ionic mechanism of the reaction.The important role of acyl azide compounds is that they can undergo Curtius rearrangement reactions to produce isocyanate-based organic compounds,which are important intermediates in drug synthesis.On the basis of the first part of our study,this work was also carried out electrolysis pool,using aldehyde compounds which are less toxic and easy to get with sodium azide as substrates,under the catalytic of halogen.A variety of reaction conditions were optimizedto determine the better reaction condition.And carried out a series of substrate development.A possible reaction mechanism was also proposed.The synthesis of pharmaceutical intermediates with reactive functional groups by electrochemical methods can effectively reduce the waste of reagents.And in some reaction selectivity,electrochemistry has its particularly unique advance.We hope to be able to further apply electrochemical applications to various fields in order to achieve better utilization of energy.