The Design And Research Of Anti-bacteria Medical Polyurethane Material

Microorganism is closely related to human activities.And its activities exist in where tthe human live in.It is a double-edged sword that it can bring benefits in the human activities,meanwhile bringing serious damage too.From ancient silver bronze to modern synthetic organic antibacterial materials and inorganic antibacterial materials,the prevention of harmful microbes--bacteria is the important job of the human activities in health care.At present,the antibacterial product involve home appliances,building materials,textile,light industry,medical,aerospace and so on.And the products just like antibacterial refrigerators,antibacterial coating,antibacterial coating clothing,and some of antibacterial catheters.And the antimicrobial catheters in medical service industry can reflect the meaning of antibacterial mostly.In recent years,with the development of medical technology,medical catheter application become more and more widely,which greatly improve the treatment level.As prime material of medical catheter,polyurethane which have good biocompatibility and excellent mechanical properties is widely used in the medical services products,such as intravascular catheter,infusion bag,dressing,etc.But as a invasive device,especially the intravascular catheter,can trigger a series of infection.For example,intravascular catheter-related bloodstream infection(CRBSI)will happen in 10% ~ 20% and the fatality rate was 25%.These infections not only brings great pain to patients,but also consume a lot of health resources,bringing medical accident and causing huge economic losses.Therefore,in order to solve this problem from the source,we need intravascular catheter with durable and excellent antibacterial performance.In this study,there are mainly two methods of antibacterial polyurethane materials processing mainly: surface modification by Light Grafting and body modification.(1)Surface modification by Light GraftingFirst synthetic azidobenzoic acid.Secondly synthetic azide chitosan and azide polyethylene glycol(peg)by azidobenzoic acid.Then graft chitosan and polyethylene glycol(peg)onto the polyurethane by Light Grafting.In this process we can study the effects of the Light Grafting with variable condition and the antibacterial performance of surface modification polyurethane.Using Infrared spectrum,nuclear magnetic resonance spectrometer and ultraviolet spectrophotometer to characterize the synthetic products.Using water contact Angle measurement to analyses the effect of Light Grafting process.using the absorbance to characterize the antibacterial properties and using SEM to analysis the morphology and structure of surface of the sample.(2)Body modificationSynthesized alkynyl polyurethane by using PCL2000 as the soft segments,six methylene diisocyanate as hard segment,2,2-propylene alkynyl-propylene glycol(DPPD)as chain extender.Using this alkynyl polyurethane material and azidobenzoic acid,Synthesized the carboxylic polyurethane by Click Chemistry in the Cu(I)catalytic conditions.Characterize the synthetic products.Finally through the antibacteria experiment,evaluate the antibacterial properties of above materials.The results show that through the modification methods above,the polyurethane materials have good antibacterial properties.