Fabrication And Biocompatibility Analysis Of Electro-active Antibacterial Materials

At present,the bone implant material of clinical application are mostly modeled bone on chemical composition and multistage of structure.Bone has the property of piezoelectric,and the blood vessels,hair and physiological activity of people,including tissue healing have electric effect.In order to achieve the best treatment effect,not only to imitate the structure of the bone,also need to imitate the piezoelectricity of bone.In the previous study,the piezoelectric ceramic was found to have well piezoelectric,and could produce electric charge under force which could promote cell proliferation,differentiation and bone integration.Implant infection is also very important in the process of bone implant.Therefore,bone implant materials with both piezoelectric and antimicrobial properties were believed to be one of the future development tendency.First,potassium sodium niobate powders were prepared by solid state reaction method,and through pressing forming,isostatic pressing,sintering and other steps in the preparation of KNN.Piezoelectric ceramic with controllable piezoelectric constant is obtained by adjusting high voltage polarization process.In view of the implant infection,antimicrobial properties and its antibacterial mechanism of KNN with different piezoelectric constant against staphylococcus aureus and escherichia coli was studied.The results showed that the positively polarized KNN has antibacterial effect,which was increased with the piezoelectric constant and when the piezoelectric constant reached +70 pC/N,it have the highest antimicrobial properties.While,the negatively polarized KNN didn't.The experimental results of Cell adhesion,proliferation and differentiation indicate that KNN with good biocompatibility as well as antimicrobial properties.In addition,to improve the wear resistance,antimicrobial properties and biological compatibility of the KNN,the tantalum and zinc composite coating was prepared by magnetron sputtering.We characterized the physicochemical properties of composite coating by SEM,EDS and contact angle,then evaluated its antibacterial property and biological performance.The results showed that,the best technology of magnetron sputtering is tantalum sputtering power of 170 w and zinc sputtering power of 60 w.The samples not only has good antiseptic effect,and has good biological activity,and also affording the solution to the not wear-resisting and easily broken of biological ceramic.This study provides the experimental and theoretical basis for the analysis of new antibacterial material and implant material.