Immunity Therapy Intensive Care Monitor

Immunotherapy often triggers high-intensity immune responses,leading to persistent fever,edema or even multiple organ failure.Therefore,a dedicated and comprehensive monitoring system is urgently needed to monitor patients in real time.However,the current clinical monitoring method lacks the vital pathological parameters,which makes it difficult for medical workers to make the accurate judgment to the state of patient.This paper presents an Intensive Care Unit monitor for immunotherapy.This instrument can carry on continuous monitoring on symptoms including shock,edema,fever and ect.Currently,this instrument has integrated the shock monitoring module.Research on edema and fever monitoring has also entered the stage of pre-clinical experiments.In this paper,the detection algorithms of water content and deep body temperature are preliminarily explored based on the functional near infrared spectroscopy.Then the monitoring probe is designed and realized on the basis of simulation,and the control circuit and software program of the instrument are developed.After the production of the instrument,the confirmatory experiment and the pre-clinical experiment were carried out.The confirmatory experimental results show that instrument designed has good sensitivity,stability and consistency of each channel response.In the pre-clinical experiment,subjects were requested to perform prescribed exercises to change their body temperature and other physiological parameters.The instrument developed monitored the status of subjects in the whole experiment.A dual-wavelength near-infrared spectrum monitor and a medical thermometer were also used for monitoring,as the control group of the experiment.Compared with the dual-wavelength near-infrared spectrum monitor,the hemoglobin concentration measured by this monitor shows a more obvious trend.The tissue water signal measured in the pre-clinical experiment contains concentration and temperature information of water.This signal shows a trend of linear increase and showed significant changes in the subjects’ motion when they stopped.This signal may be of potential value in monitoring inflammation and other clinical symptoms.At the same time,the difference between temperature measured by this instrument and thermocouple thermometer is small(the average is 0.15 degrees Celsius).The above experimental results show that the four wavelength monitoring method is more advantageous than the dual wavelength method,and also verify that the instrument developed can measure the water content and the tissue temperature in the allowable error.In this paper,preliminary detection algorithms of water content and deep body temperature are obtained.An Intensive Care Unit monitor is designed and partially realized.A pre-clinical experiment for detecting human blood parameters and other information is designed and carried out.This study obtains a lot of achievements in the noninvasive monitoring of water content,fat content and deep body temperature.It also shows reference value and potential application value in intensive care,multi physiological parameter monitoring and other fields.In further study,a large number of clinical trials will be carried out to optimize the algorithm and establish evaluation models of edema and other symptoms.