| Objectives: To explore the treatment perscription by which different doses of acarbose in the initial treatment of newly diagnosed type 2 diabetes mellitus(T2DM),to apply acarbose 50 mg,tid;100mg,tid initial treatment of newly diagnosed T2 DM and to observe the clinical efficacy and safety of the application of different doses of acarbose in the treatment of newly diagnosed T2 DM.Methods: After a 4 weeks period of life style intervention,120 cases of newly diagnosed T2 DM patients were randomly divided into two groups and received two different dose of acarbose ie.50 mg,tid and 100 mg,tid treatment respectively for a period of 24 weeks.Test the glycated hemoglobin(HbA1c),fasting blood glucose(FBG),postprandial 2 hours blood glucose(2 HPBG),triglyceride(TG),total cholesterol(TCH),high-density lipoprotein(HDL-C),low density lipoprotein(LDL-C),alanine aminotransferase(ALT),aspertate aminotransferase(AST),fasting insulin,C peptide,fasting free fatty acids(FFA),NUCB2 codes for the effect of fat protein(Nesfatin – 1)test indicators,etc.At the baseline,12 th week and 24 th week.Calculate BMI change situation in all patients and understand the incidence of gastrointestinal adverse reactions.Results:1 After 12 weeks treatment,compare with that before treatment,body mass index,weight,waist circumference and other index and numerical value in both groups were all decreaseded(P < 0.05),and the decrease range in high-dose group is greater than in low-dose group,the difference was statistically significant(P < 0.05).2 After 12 weeks treatment,compare with that before treatment,fasting glucose,postprandial 2 hours blood glucose,glycosylated hemoglobin in both groups were decreased(P < 0.05),and the decrease range in high-dose group is greater than in low-dose group,the difference was statistically significant(P < 0.05).3 After 12 weeks treatment,compare with that before treatment,the total cholesterol,triglycerides,low density lipoprotein level in both groups were decreased(P < 0.05),and the decrease range in high-dose group is greater than in low-dose group,the difference was statistically significant(P < 0.05).After 12 weeks treatment,also compare with that before treatment,the high density lipoprotein level in both groups were increased(P < 0.05),and the increase range in high-dose group is greater than in low-dose group,the difference was statistically significant(P < 0.05).4 After 12 weeks treatment,compare with that before treatment,valley fasting insulin in both groups were decreased(P < 0.05),and the decrease range in high-dose group is greater than in low-dose group,the difference was statistically significant(P < 0.05).After 12 weeks treatment,also compare with that before treatment,C peptide levels in both groups were decreased(P < 0.05),and the decrease range in high-dose group is greater than in low-dose group,the difference was statistically significant(P < 0.05).5 After 12 weeks treatment,compare with that before treatment,fasting plasma FFA level in both groups were decreased(P < 0.05),and the decrease range in high-dose group is greater than in low-dose group,the difference was statistically significant(P < 0.05).After 12 weeks treatment,also compare with that before treatment,Nesfatin 1 levels in both groups were increased(P < 0.05),and the increase range in high-dose group is greater than in low-dose group,the difference was statistically significant(P < 0.05).6 After 12 weeks treatment,compare with that before treatment,there was no significant change(P > 0.05)in central third aminotransferase level,aspertate aminotransferase level,and there was no significant statistically difference(P < 0.05)between the high-dose group and the low-dose group.7 After 24 weeks treatment,compare with that before treatment,body mass index,weight,waist circumference in both groups were decreased(P < 0.05),and the decrease range in high-dose group is greater than in low-dose group,the difference was statistically significant(P < 0.05).8 After 24 weeks treatment,compare with that before treatment,fasting glucose,postprandial 2 hours blood glucose,glycosylated hemoglobin in both groups were decreased(P < 0.05),and the decrease range in high-dose group is greater than in low-dose group,the difference was statistically significant(P < 0.05).9 After 24 weeks treatment,compare with that before treatment,the total cholesterol,triglycerides,low density lipoprotein level in both groups were decreased(P < 0.05),and the decrease range in high-dose group is greater than in low-dose group,the difference was statistically significant(P < 0.05).After 24 weeks treatment,also compare with that before treatment,the high-density lipoprotein cholesterol after 24 weeks of treatment levelin both groups were increased(P < 0.05),and the increase range in high-dose group is greater than in low-dose group,the difference was statistically significant(P < 0.05).10 After 24 weeks treatment,compare with that before treatment,valley fasting insulin levels in both groups were decreased(P < 0.05),and the decrease range in high-dose group is greater than in low-dose group,the difference was statistically significant(P < 0.05).After 24 weeks treatment,also compare with that before treatment,C peptide levels in both groups were decreased(P < 0.05),and the decrease range in high-dose group is greater than in low-dose group,the difference was statistically significant(P < 0.05).11 After 24 weeks treatment,compare with that before treatment,fasting plasma FFA level in both groups were decreased(P< 0.05),and the decrease range in high-dose group is greater than in low-dose group,the difference was statistically significant(P < 0.05).After 24 weeks treatment,also compare with that before treatment,Nesfatin 1 levels in both groups were increased(P < 0.05),and the increase range in high-dose group is greater than in low-dose group,the difference was statistically significant(P < 0.05).12 After 24 weeks treatment,compare with that before treatment,there was no significant change(P > 0.05)in cereal third transaminase levels,aspertate aminotransferase levels,and there was no significant statistically difference(P < 0.05)between the high-dose group and the low-dose group.13 After 24 weeks of treatment,body mass index,weight and waist circumference of low-dose group were lower than those after12 weeks of treatment,and the difference was statistically significant(P < 0.05).After 24 weeks of treatment,body mass index,weight and waist circumference of high-dose group were also lower than those after12 weeks of treatment,and the difference was also statistically significant(P < 0.05).Body mass index,weight and waist circumference of the high-dose group were lower than those of the low-dose group(P < 0.05),the difference was statistically significant(P < 0.05).Body mass index,weight and waist circumference of the high-dose group after 24 weeks of treatment were lower than those of the low-dose group(P < 0.05),the difference was statistically significant(P < 0.05).14 After 24 weeks of treatment,fasting blood glucose,blood sugar 2 hours after meal and glycosylated hemoglobin of low-dose group were lower than those after12 weeks of treatment,and the difference was statistically significant(P < 0.05).After 24 weeks of treatment,fasting blood glucose,blood sugar 2 hours after meal and glycosylated hemoglobin of high-dose group were also lower than those after12 weeks of treatment,and the difference was also statistically significant(P < 0.05).Fasting blood glucose,blood sugar 2 hours after meal and glycosylated hemoglobin of the high-dose group were lower than those of the low-dose group(P < 0.05),the difference was statistically significant(P < 0.05).Fasting blood glucose,blood sugar 2 hours after meal and glycosylated hemoglobin of the high-dose group after 24 weeks of treatment were lower than those of the low-dose group(P < 0.05),the difference was statistically significant(P < 0.05).15 After 24 weeks of treatment,total cholesterol,triglyceride and low density lipoprotein cholesterol of low-dose group were lower than those after12 weeks of treatment,and the difference was statistically significant(P < 0.05).After 24 weeks of treatment,total cholesterol,triglyceride and low density lipoprotein cholesterol of high-dose group were also lower than those after12 weeks of treatment,and the difference was also statistically significant(P<0.05).Total cholesterol,triglyceride and low density lipoprotein cholesterol(hdl-c)of the high-dose group were lower than those of the low-dose group(P < 0.05),the difference was statistically significant(P < 0.05).Total cholesterol,triglyceride and low density lipoprotein cholesterol of the high-dose group after 24 weeks of treatment were lower than those of the low-dose group(P < 0.05),the difference was statistically significant(P < 0.05).After 24 weeks of treatment,high-density lipoprotein cholesterol of low-dose group were higher than those after12 weeks of treatment,and the difference was statistically significant(P < 0.05).After 24 weeks of treatment,high-density lipoprotein cholesterol of high-dose group were also higher than those after12 weeks of treatment,and the difference was also statistically significant(P < 0.05).High-density lipoprotein cholesterol of the high-dose group were higher than those of the low-dose group(P < 0.05),the difference was statistically significant(P < 0.05).High-density lipoprotein cholesterol of the high-dose group after 24 weeks of treatment were higher than those of the low-dose group(P < 0.05),the difference was statistically significant(P < 0.05).16 After 24 weeks of treatment,fasting insulin of low-dose group were lower than those after12 weeks of treatment,and the difference was statistically significant(P < 0.05).After 24 weeks of treatment,fasting insulin of high-dose group were also lower than those after12 weeks of treatment,and the difference was also statistically significant(P < 0.05).Fasting insulin of the high-dose group were lower than those of the low-dose group(P < 0.05),the difference was statistically significant(P < 0.05).Fasting insulin of the high-dose group after 24 weeks of treatment were lower than those of the low-dose group(P < 0.05),the difference was statistically significant(P < 0.05).After 24 weeks of treatment,C peptide levels of low-dose group were higher than those after12 weeks of treatment,and the difference was statistically significant(P < 0.05).After 24 weeks of treatment,C peptide levels of high-dose group were also higher than those after12 weeks of treatment,and the difference was also statistically significant(P < 0.05).C peptide levels of the high-dose group were higher than those of the low-dose group(P < 0.05),the difference was statistically significant(P < 0.05).C peptide levels of the high-dose group after 24 weeks of treatment were higher than those of the low-dose group(P < 0.05),the difference was statistically significant(P < 0.05).17 After 24 weeks of treatment,fasting plasma FFA of low-dose group were lower than those after12 weeks of treatment,and the difference was statistically significant(P < 0.05).After 24 weeks of treatment,fasting plasma FFA of high-dose group were also lower than those after12 weeks of treatment,and the difference was also statistically significant(P < 0.05).Fasting plasma FFA of the high-dose group were lower than those of the low-dose group(P < 0.05),the difference was statistically significant(P < 0.05).Fasting plasma FFA of the high-dose group after 24 weeks of treatment were lower than those of the low-dose group(P < 0.05),the difference was statistically significant(P < 0.05).After 24 weeks of treatment,Nesfatin-1 of low-dose group were higher than those after12 weeks of treatment,and the difference was statistically significant(P < 0.05).After 24 weeks of treatment,Nesfatin-1 of high-dose group were also higher than those after12 weeks of treatment,and the difference was also statistically significant(P < 0.05).Nesfatin-1 of the high-dose group were higher than those of the low-dose group(P < 0.05),the difference was statistically significant(P < 0.05).Nesfatin-1 of the high-dose group after 24 weeks of treatment were higher than those of the low-dose group(P < 0.05),the difference was statistically significant(P < 0.05).18 There was no statistically significant difference(P > 0.05)in cereal third transaminase levels and aspertate aminotransferase levels between the index after 24 weeks of treatment and the index after 12 weeks of treatment in the low-dose group.There was no statistically significant difference(P > 0.05)in cereal third transaminase levels and aspertate aminotransferase levels between the index after 24 weeks of treatment and the index after 12 weeks of treatment in the high-dose group.There was no statistically significant difference(P > 0.05)in cereal third transaminase levels and aspertate aminotransferase levels between the low-dose group and the high-dose group both after 12 weeks of treatment and after 24 weeks of treatment.19 After 12 weeks of treatment,the incidence of hypoglycaemia in low-dose group and high-dose group are respectively 11.67%(7 cases)and 15.00%(9 cases).There was no statistically significant difference(chi-square = 0.2885,P=0.2885,P > 0.05)in the comparison between the two groups in the incidence of hypoglycemia.The incidence of hypoglycaemia in low-dose group and high-dose group are respectively 16.67%(10 cases)and 18.33%(11cases)after 24 weeks of treatment,.There was no statistically significant difference(chi-square = 0.8333,P = 0.8333,P > 0.05)in the comparison between the two groups in the incidence of hypoglycemia.20 After 12 weeks of treatment,the incidence of gastrointestinal reaction in low-dose group and high-dose group are respectively 8.33%(5 cases)and 11.67%(7 cases).There was no statistically significant difference(chi-square = 0.3704,P = 0.3704,P > 0.05)in the comparison between the two groups in the incidence of gastrointestinal reaction.The incidence of gastrointestinal reaction in low-dose group and high-dose group after 24 weeks of treatment are respectively 11.67%(7 cases)and 15.00%(9 cases).There was no statistically significant difference(chi-square = 0.6168,P = 0.6168,P>0.05)in the comparison between the two groups in the incidence of gastrointestinal reaction.Gastrointestinal reaction characterized by abdominal distension,,diarrhea and increased exhaust,alleviate by the patient himself after 2 to 4 weeks.Conclusions:1 Different dose of acarbose in newly diagnosed T2 DM patients with body mass index,body weight,waist circumference has improved,the 100 mg dose of acarbose in newly diagnosed T2 DM patients with body mass index,body weight,waist circumference,better results than the 50 mg dose of acarbose.2 Different dose of acarbose in newly diagnosed T2 DM patients with glycemic index were improved,the glycemic index of 100 mg dose of acarbose in newly diagnosed T2 DM patients with better results than the 50 mg dose of acarbose.3 Different dose of acarbose in newly diagnosed T2 DM patients serum lipid indexes were improved,the 100 mg dose of acarbose in newly diagnosed T2 DM patients with blood lipid indicators better than 50 mg dose of acarbose.4 Different dose of acarbose in newly diagnosed T2 DM patients with fasting insulin and C-peptide levels have improved,the 100 mg dose of acarbose in newly diagnosed T2 DM patients with fasting insulin and C-peptide levels better than 50 mg dose of acarbose.5 Different dose of acarbose in newly diagnosed T2 DM patients fasting FFA,nesfatin-1 has improved,the 100 mg dose of acarbose in newly diagnosed T2 DM patients fasting FFA,nesfatin-1 better results than the 50 mg dose of acarbose.6 Newly diagnosed type 2 diabetes patients with oral 100 mg dose of acarbose,its security and oral 50 mg dose of acarbose. |
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