Relationship Analysis Between Plasma Level Of Homocysteine And Acute Myocardial Infarction With Type 2 Diabetes

Objective: Previous studies have shown that high homocysteine(HCY)is one of the important risk factors in type 2 diabetes(T2DM)complicated with cerebral infarction,but it is not very clear that the relationship between high HCY and type 2 diabetes with acute myocardial infarction(AMI).This study is to explore the relationship between HCY and type 2 diabetes with acute myocardial infarction.Methods: Forty patients with type 2 diabetes(T2DM)and forty-two patients with type 2 diabetes with acute myocardial infarction(T2DM+AMI)were randomly selected in our hospital.The general clinical characteristics,blood glucose,glycosylated hemoglobin,cholesterol,high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),triglycerides,high sensitivity C reactive protein(hs-CRP)and HCY were compared between two groups.The independent risk factors of type 2 diabetes with acute myocardial infarction were analyzed using Logistic regressing analysis method.Results: There was no statistical difference between two groups in age,gender ratio,body mass index(BMI),drinking history(P>0.05).The smoking rate was 30% in type 2 diabetes and 57% in type 2 diabetes with acute myocardial infarction,there was a significant difference between two groups(P<0.05).The ratio of high blood pressure was 60% in type 2 diabetes and83% in type 2 diabetes with acute myocardial infarction,there was a significant difference between two groups(P<0.05).There was no statistical difference between two groups in blood lipid level including cholesterol,high density lipoprotein-cholesterol,low density lipoprotein-cholesterol and triglycerides(all P>0.05).There was no statistical difference between two groups in blood glucose and glycosylated hemoglobin levels(P>0.05).Thehs-CRP was significantly higher in type 2 diabetes with acute myocardial infarction than in type 2 diabetes group(14.3±3.7 mg/L vs 5.6±2.0 mg/L,respectively,P<0.05).The HCY was significantly higher in type 2 diabetes with acute myocardial infarction than in type 2 diabetes group(29.25±8.11?mol/L vs 18.13± 4.65?mol/L,respectively,P<0.05).Smoking history and HCY level were both independent risk factors in type 2 diabetes with acute myocardial infarction by logistic regressing analysis.Conclusion: Smoking history and HCY level were the important risk factors in patients with type 2 diabetes with acute myocardial infarction.Blood glucose and lipid level should be regularly controlled,meanwhile,smoking cessation and HCY level shoule be pay more attention in type 2diabetes patients in order to reduce the incidence of acute myocardial in farction.