| BackgroundProton pump inhibitors(PPIs)were widely used in clinical because of its characteristics that powerful,lasting acid suppression function and the low toxicity.It produced a good effect in the treatment of acid related diseases and prevention of non-steroidal anti-inflammatory drugs related to the gastrointestinal bleeding.But with the widely application of proton pump inhibitors in clinical,an increasing number of studies have evaluated the long-term side effects of PPI use.Whether long-term use of PPI will increase the risk of small intestinal bacterial overgrowth(SIBO)occurred,we performed an observational study in our study.PurposeThe objective of our study was to investigate the correlation of PPI and SIBO and to observe the association between medication time of PPIs and the SIBO incidence.And to observe the correlation between SIBO and gastrointestinal symptom rating scale(GSRS)of the digestive tract symptoms such as abdominal distension,abdominal pain,diarrhea,constipation in patients with long-term use of PPIs.It is used to guide clinical PPI applications. MethodsWe used prospective controlled studies collected patients in digestive department of the Zhengzhou people’s hospital who need regular doses of proton-pump inhibitors in January 2014 to January 2015.Patients mainly included gastro-esophageal reflux disease.In our study,38 patients who was treatment with PPIs in observation group,20 healthy volunteers who does not accept any treatment in control group,all subjects were prospectively assessed by lactulose hydrogen breath test(LHBT)and gastrointestinal symptom rating scale(GSRS).The data were then subjected to statistical analysis.ResultsBefore the PPI therapy,the prevalence of SIBO is 13.15% in observation group,while it is 10.00% in control group.There were no statistically significant differences between two groups.After 8,24 weeks the respectively prevalence of SIBO is 42.1%(16/38),71.42%(15/21)in PPI therapy group,15.0%(3/20),10.0%(2/20)in the volunteer group.Significant difference was found between the PPI group and the volunteer group(p<0.001),a positive relationship was found between the SIB0 positive rate and the length of time taking PPI(r=1,p<0.0001).The score of distension and diarrhea in SIB0 positive were significantly higher than SIBO negative group in the observation group at 8 weeks and 24 weeks(p<0.05).Conclusions1)Assessed by LHBT,the incidence of SIBO in long-term PPI users is higher than the control group.And it increased with the medication time delay.2)In patients of Long-term use PPI,the incidence of abdominal distention,diarrhea in SIBO positive group was obviously higher than that of SIBO negative. |
