| Research purpose: Through the observation of changes of their sleep structure, Hamilton Depression Scale(HAMD) scores and Pittsburgh Sleep Quality Index(PSQI) scores around 12 weeks before and after the application of Paroxetine to patients with depression after cerebral infarction, this paper aims to adjust their sleep structure and estimate their state of depression.Methodology: The outpatients of our hospital meeting the inclusion criteria were selected, and based on the principle of randomized control, the patients were divided into treatment group and control group. After grouping, patients in control group were treated by some ordinary medicine for cerebral infarction, whereas excepting taking ordinary medicine, patients in treatment group took an extra pill of 20 mg Paroxetine per day. The whole treatment process was being monitored by Polysomnography(PSG). After 12 weeks, software of spss20.0 was applied to analyze the HAMD, PSQI scores and PSG data.Results: 1. According to inclusion criteria, 56 outpatients of our hospital with depression after cerebral infarction were selected, among which there were 29 men, 27 women with age between 51 and 59, and the average age is 62.80±6.877. There were no distinctive differences between treatment group and control group in terms of age, gender, education level(p > 0.05). 2. Before treatment, the HAMD scores in treatment group and control group are 33.05±5.095 and 33.07±4.650 respectively, and PSQI scores are 15.46±2.472 and 15.79±1.707 respectively. No significant difference was found in these two groups(P>0.05), which indicated the baseline levels are basically the same. 3. There was no significant difference were observed between the treatment group and control group in sleep latency(SL), REM sleep latency period(RL), 1 sleep scale(S1%), 2 sleep scale(S2%), stage 3 sleep scale(S3%) and the proportion of REM sleep(R%) at baseline(P>0.05). There is significant difference in sleep efficiency(SE) between treatment group and control group(71.1±12.17, 60.86±15.63 respectively, P<0.05), and REM sleep time(RT)(49.26±31.41, 33.63±25.34 respectively, p < 0.05). Although there are differences between SE and RT, the sleep structure is basically consistent in two groups. 4. The PSQI points and S3% decreased in the control group after treatment(15.25±1.65 and 15.14±12.22 respectively), and SE and S2% increased after treatment(62.51±15.84 and 61.44±16.97), and there is statistical significance between before and after treatment(P<0.05). There were no significant differences for control group in HAMD, SL, RL, S1% and R% between before and after treatment(p>0.05). It indicated patients have subjective sleep improvement, however, the depression symptom and sleep structure was not improved. 5. There is significant difference in the treatment group between before and after treatment in HAMD scores(33.07±5.10, 16.87±1.27 respectively, P<0.05), PSQI scores(15.46±2.47, 7.21±1.88 respectively, P<0.05), SE(71.13±12.18, S87.40±6.18 respectively, P<0.05), SL(33.54±27.8, 23.08±14.73 respectively, P<0.05), S1%(11.67±9.65, 12.42±9.10 respectively, P<0.05), S2%(62.43±14.71, 46.93±6.71 respectively, P<0.05), S3%(12.67±9.56, 23.30±6.49 respectively, P<0.05) and R%(13.22±7.57, 17.39±6.19 respectively, P<0.05). It indicated after taking Paroxetine for 12 weeks, patients’ symptom of depression and insomnia were greatly improved. 6. There is statistical significance between the treatment group and control group after treatment in HAMD(16.86±1.27, 32.86±4.37 respectively, P<0.05), PSQI(7.21±1.87, 15.25±16.45 respectively, P<0.05), SE(87.37±6.18, 62.51±15.83 respectively, P<0.05), SL(23.08±14.73, 59.03±55.09 respectively, P<0.05), S2%(46.93±6.71, 61.44±16.97 respectively, P<0.05), S3%(23.23±6.49, 15.15±12.23 respectively, P<0.05), R%(17.36±6.19, 11.51±6.96 respectively, P<0.05), and RT(67.28±25.83, 34.59±25.32 respectively, P<0.05). There is no significance in S1% and RL. It showed the symptom of depression was improved more and had a better effect on sleep structure with the use of Paroxetine in combination with ordinary medicine than ordinary medicine alone.Conclusion: Depression symptom in patients with depression after cerebral infarction has improved within 12 weeks after the treatment of Paroxetine. And with the treatment of Paroxetine, it can increase the duration of deep sleep, and decrease the duration of light sleep. However, the change of rapid eye movement latency is not obvious. |
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