Analysis Of Breast Cancer Molecular Subtypes Associated With Clinical Characteristics And Correlation Analysis Of Magnesium Asso Ciated With Lymph Node Metastasis Of Breast Cancer

Objective: To investigate the correlation between different molecular subtypes of breast cancer and four factors,including primary lesion location,axillary lymph node metastasis,blood type,and menstruation;to preliminarily explore the correlation between serum magnesium ion concentration and axillary lymph node metastasis of breast cancer.Methods: One hundred and seventy-one naive patients with breast cancer were enrolled in Department of breast surgery from Liaoning Cancer Hospital.All patients were required to have complete pathological data and have received no pre-operative anti-tumor therapy.Based on immunohistochemistry method and in situ hybridization assessment(ISH),patients were divided into five types after operation: patients with Luminal A breast cancer,patients with Luminal B HER-2 negative breast cancer,patients with Luminal B HER-2 positive breast cancer,patients with HER-2 positive breast cancer and patients with triple-negative breast cancer.The correlation between different molecular subtypes of breast cancer and several clinical characteristics were investigated.And the relationship between serum magnesium ion and axillary lymph node metastasis of breast cancer were explored.Results: One hundred and seventy-one patients were enrolled in this study,including Luminal A breast cancer in 33 cases(19.3%),Luminal B HER-2 negative breast cancer in 67 cases(39.2%),Luminal B HER-2 positive breast cancer in 18 cases(10.5%),HER-2 positive breast cancer in 18 cases(10.5%)and triple-negative breast cancer in 35 cases(20.5%).Differences between different molecular subtypes of breast cancer and lesion location were found(P=0.028).To be specific,right lesion was likely to be in Luminal B Her-2-negative breast cancer(P =0.011)while left lesion in triple-negative breast cancer(P =0.006).No statistical differences between different molecular subtypes of breast cancer and axillary lymph node metastasis(P =0.476)were indicated.Lymph node metastasis was divided into four groups according to the number of metastasis in N stage of TNM stage.Statistical analysis of different molecular subtypes of breast cancer and lymph node metastasis was performed,and no statistical differences was found(P =0.403).No statistical differences between different molecular subtypes of breast cancer and menstruation(P =0.131).However,HER-2 positive breast cancer,including Luminal B HER-2-positive and HER-2 positive breast cancer,was likely to happen to postmenopausal patients.The percentage of postmenopausal patients with HER-2 positive breast cancer was 66.67% while the percentage of Luminal B HER-2-positive breast cancer was 72.22%.No statistical differences between different molecular subtypes of breast cancer and blood types(P =0.409).And no statistical differences between the occurrence of axillary lymph node metastasis and the concentration of magnesium ion were indicated(P=0.061).As was demonstrated,lower magnesium ion concentration was not the risk factor of axillary lymph node metastasis by unconditional binary logistic regression.Conclusion: Right lesion was more likely to be in Luminal B Her-2 g-negative breast cancer while left lesion in triple-negative breast cancer.No statistical differences between different molecular subtypes of breast cancer and menstruation.HER-2 positive breast cancer,including Luminal B HER-2-positive and HER-2-positive breast cancer,was likely to happen to postmenopausal patients.No statistical differences between different molecular subtypes of breast cancer and blood types,but patients of blood type A were more likely to develop breast cancer.No statistical differences between different molecular subtypes of breast cancer and magnesium ion concentration.