The Clinical Study Of Early Intervation Of The Spontaneous Abortion Before Thrombosis Based On Reinforging Kidney And Activating Blood Circulation Therapy

1 Objective:To observe the clinical efficacy on treatment of early intervation of the Spontaneous abortion before thrombosis based on reinforging kidney and activating blood circulation therapy and to study the possible effective mechanism.2 Methods:50 patients who conform to the diagnosis standard of the spontaneous abortion before thrombus state and meet the conditions set were randomly divided into treatment group and control group, 25 cases in each group. The patients of treatment group take the TCM medicine of reinforging kidney and activating blood circulation and aspirin.The patients of control group take the aspirin. Continuous served three months for a period of treatment. To check related laboratory indexes during treatment once every half month. If patients' laboratory indexes drop to normal during treatmen, we record the time needed for discontinuation and guide them to pregnancy. To take active treatment after pregnancy miscarriage and to observe the success of pregnancy than usual abortion in more than 2 weeks. It is not normal to continue treatment until the end of a period of treatment. To evaluate patients' TCM symptoms efficacy, TCM single symptom efficacy and TCM symptoms total score before and after treatment, and to evaluate the time needed for laboratory index dropped to normal and the successful pregnancy. We observe the levels of D-dimer, Fibrin degradation products in serum and the laboratory indexes of blood coagulation routine before and after treatment. Above all do statistical processing.3 Results:(1) Evaluation of patients' TCM symptoms efficacy: For the treatment group, the toal effectiveness had achieved 96%. For the control group, the toal effectiveness was76%. The difference was statistically significant(P<0.05).(2) Evaluation of patients' TCM single symptom efficacy : Compared with the control group,the treatment group is better in improving clinical single TCM single symptom efficacy. The difference is statistically significant(P<0.05).(3) Evaluation of patients' TCM symptoms total score: the comparison of TCM symptoms total score of the two groups' is not significant before treatment(P>0.05),which is comparable. But it is statistically significant in the two groups before and after the treatment and after treatment(P<0.05).(4) Evaluation of the successful pregnancy: There are 23 patients' laboratory index into group dropped to normal after treatment in the treatment group. There are 20 cases of pregnancy, with 18 cases being successful pregnancy, 2 cases abortion, and the successful preagnancy rate is 90%. There are 22 patients' laboratory index into group dropped to normal after treatment in the control group. There are 19 cases of pregnancy,with 11 cases being successful pregnancy, 8 cases abortion, and the successful preagnancy rate is 58%. Pregnancy outcomes in both groups have significant differences(P<0.05).(5) Evaluation of the time needed for laboratory index dropped to normal during the treatment: The time of the treatment group's laboratory index dropped to normal is1.17 ± 0.70 months, and the time of the control group is 1.70 ± 0.81 months. The difference was statistically significant(P<0.05). There are 14 cases whose laboratory index dropped to normal taking a month or less in the treatment group, accounting for61%, 7 cases taking two months or less, accounting for 30%, 2 cases taking three months or less, accounting for 9%. There are 7 cases whose laboratory index dropped to normal taking a month or less in the control group, accounting for 32%, 9 cases taking two months or less, accounting for 41%, 6 cases taking three months or less, accounting for 27%.(6) Evaluation of relevant laboratory indexes before and after treatment: the levels of serum D-D and FDP of the two groups before treatment is not statistical significance(P>0.05), which is comparable. The comparison difference in the two groups before andafter treatment is statistical significance(P<0.05). And the comparison difference in the two groups after treatment is not statistical significance(P>0.05). The statistical analysis of the four indicators of blood coagulation: There is no significant difference compared with the four indicators of blood coagulation in the two groups before and after treatment(P>0.05), which is comparable. PT: There is no significant difference compared in the two groups before and after treatment(P>0.05). APTT: It has a significant difference compared before and after treatment in the two groups(P<0.05).And the comparison difference in the two groups after treatment is not statistical significance(P>0.05). Fbg?TT:The comparison difference in the two groups before and after treatment is statistical significance(P<0.05), and after treatment is statistical significance(P<0.05).4 Conclusion:The treatment based on reinforging kidney and activating blood circulation therapy collaborative aspirin of spontaneous abortion prethrombotic state is effective distinctly.It can improve patients' TCM symptoms efficacy, TCM single symptom efficacy and TCM symptoms total score significantly and the successful rate of patients with pregnancy is increased significantly. Its mechanism may be related to the traditional Chinese medicine of reinforging kidney and activating blood circulation therapy regulating abnormality of serum D-D, FDP, the relevant indexes from the four indicators of blood coagulation, and improving prethrombotic state.