Research On The Effects Of Rosuvastatin And Atorvastatin To The Dynamic Changes In Levels Of Plasma SOX40L, Lp-PLA₂, Hs-CRP, LDL And Neural Function In Patients With Acute Cerebral Infarction

Objective: To observe the effects of the different dosage of rosuvastatin and atorvastatin to the dynamic changes in levels of plasma soluble OX40 ligand?sOX40L?, lipoprotein-associated phospholipase A2?Lp-PLA₂?, highsensitivity C-reactive protein?Hs-CRP?, low density lipoprotein cholesterol?LDL?, and neural function in patients with acute cerebral infarction. Meanwhile, try to illuminate the pathogenesis of the plasma sOX40 L, Lp-PLA₂, Hs-CRP after stroke.Method: Collect 59 cases of the patients who sufferring the acute cerebral infarction and receive inpatient treatment on March to November 2015 in the Second Hospital of Hebei Medical University, Department of Neurology, which 43 cases were male and 16 females, age range 30 to 80 years old. The participates were divided into three groups: control group?n=19?, rosuvastatin group?rosuvastatin 10mg/d, n=20? and atorvastatin group?atorvastatin 20mg/d, n=20?. All three the treatment course were 10 days. Taken the participate's blood on the first and tenth day separately, record the basically data and marked the score of NIHSS at the same time. ELISA box was used to detect the levels of plasma sOX40 L, while Lp-PLA₂, Hs-CRP, CHOL, TG, LDL, HDL and were measured by Biochemical and Immunological Department. All the data collected were analyzed by SPSS 21.0 statistic software. Measurement data were described as mean±standard deviation. If data distribution meet the coincidence with the normality and variance, complete randomized analysis of variance should come to the first. If not, multiple independent samples non-parametric tests, Kruskal-Wallis H Test, would be a better choice. Count data compared with in group should use R×C chi-square test. Set the significance level ?=0.05, with P<0.05 was considered statistically significant. Spearman rank correlation was optional for the nonparametric test correlation analysis, set the significance level ?=0.01, with P<0.01 was considered both of them were in correlated.Results: 1 The constituent ratio include age and gender among the following groups, control group?n=19?, rosuvastatin group?n=20? and atorvastatin group?n=20?, has no significant difference in statistics. Similarly, the levels of HDL and HCY are consistent with the result above?P>0.05?; the past medical history on hypertension, diabetes, acute coronary disease and past stroke are consistent with the result above?P>0.05?; the bad behavior referred to drinking and smoking are consistent with the result above?P>0.05?; 2 The control group, the rosuvastatin group, atorvastatin group, before treatment, which the levels of plasma sOX40 L of patients of the three groups were no significance statistically?P=0.975, P>0.05?; after treatment, which the levels of plasma sOX40 L were increased, but there's no significance statistically?P=0.456, P>0.05?; 3 The three groups of patients before treatment the levels of Lp-PLA₂ were not statistically significant?P=0.496, P>0.05?; after treatment, the levels of Lp-PLA₂ were declined, but there's no significance statistically?P=0.905, P>0.05?; 4 The three groups of patients before treatment the levels of Hs-CRP were not significance statistically?P=0.165, P>0.05?; after treatment the levels of Hs-CRP no significance statistically?P=0.152, P>0.05?; 5 The three groups of patients before treatment the levels of CHOL was no significance statistically?P=0.56, P>0.05?; after treatment the levels of CHOL declining trend, and there was significance statistically?P=0.003, P<0.05?; 6 Compared with the numerical of difference before and after treatment the levels of CHOL showed rosuvastatin group, atorvastatin group are difference with control group, and there was significance statistically; But compared rosuvastatin group with atorvastatin, there was no significance statistically; 7 The three groups of patients before treatment the levels of LDL was no significance statistically?P=0.515, P>0.05?; after treatment the levels of LDL declining trend, and there was significance statistically?P=0.003, P<0.05?; 8 Compared with the numerical of difference before and after treatment the levels of LDL showed rosuvastatin group, atorvastatin group are difference with control group, and there was significance statistically; But compared rosuvastatin group with atorvastatin, there was no significance statistically; 9 The three groups of patients before treatment the levels of TG were not significance statistically?P=0.162, P>0.05?; after treatment the levels of TG no significance statistically?P=0.621, P>0.05?; 10 The excellence rate between the three group has no significance statistically?P=0.314, P>0.05?, while the utility rate has significance statistically?P=0.016, P<0.05?; 11 Before and after treatment, the inflammatory marks the plasma s OX40 L has no correlation with NIHSS?P>0.01?; before treatment, Lp-PLA₂ has correlation with NIHSS?P=0.001, P<0.01?, but after treatment Lp-PLA₂ has no correlation with NIHSS?P=0.276, P>0.01?; before treatment, the serum Hs-CRP has correlation with NIHSS?P=0.006, P<0.01?, but after treatment Hs-CRP has no correlation with NIHSS?P=0.133, P>0.01?.Conclusion:1 Which rosuvastatin and atorvastatin can significantly decreased the levels of CHOL and LDL, 10 mg of rosuvastatin and 20 mg of atorvastatin were no significant difference in lipid-lowering aspects.2 Which rosuvastatin and atorvastatin have efficiency on acute cerebral infarction, 10 mg of rosuvastatin and 20 mg of atorvastatin were no significance statistically in terms of significant efficiency.3 Plasma sOX40 L may not be suitable as a serological marker of acute cerebral infarction, or rosuvastatin has a faint effect on regulate it, or atorvastatin has a faint effect on regulate it.4 Rosuvastatin and atorvastatin may have unclearly effects on Lp-PLA₂, Hs-CRP's, or may have faint effects on regulate those.5 Lp-PLA₂, and Hs-CRP can be used as serological markers on acute cerebral infarction, which are significant correlation with disease in terms of the assessment, but there are no significant correlation with the prognosis.