Therapeutic Effect Of Nicorandil On Non ST Elevation Myocardial Infarction After Percutansneous Coronary Intervention

Objective:To expiore the clinical effect of Nicorandil on non ST elevation myocardial infarction after percutansneous coronary intervention,observe the effect of cardiovascular events incidence rate of nicorandil in the treatment of non ST elevation myocardial infarction after percutansneous coronary intervention such as angina pectoris and cardial insufficiency and arrhythmia and so on.Methods:Chose 90 non ST elevation myocardial infarction patients with percutansneous coronary intervention in our section,90 patients were randomly divided into observation group(received nicorandil 5-10 mg based on routoine medication,three times/day)and control group(routoine treatment group),the observation group including 22 male patients and 23 female patients,age 43 ~77 years old,average age 54±5.7.the control group including 25 male patients and 20 female patients,age 45 ~76 years old,average age 56.2±6.5.the difference was no statistically significant(Ρ>0.05)for the comparison.two groups received conventional medical treatment,the control group taked nicorandil additionally(5-10 mg,three times/day).Comparing curative effect and cardiovascular events recurrence of angina pectoris and hart insufficiency and arrhythmia after three months treatment of two groups.Results: 1.Recurrent Angina pectorisA total of 14 patients recur angina symptoms in observation group.eight cases of grade Ⅰ,four cases of grade Ⅱ,one case of grade Ⅲ,one case of grade Ⅳ;18 patients recur angina symptoms in control group,eight cases of grade Ⅰ,four cases of grade Ⅱ,three cases of grade Ⅲ,three cases of grade Ⅳ;The difference was no statistically significant(Ρ>0.05)for the comparison of the recurrence rate,But the incidence of grade Ⅲ and grade Ⅳ in observation group was obviously lower than the control group,the differences between the two groups have statistical significance(P < 0.05).2.Comparison of Left ventricular activity scores and Left ventricular ejection fraction(LVEF)%:Left ventricular activity scores and ejection fraction(LVEF)% obviously improved in observation group than control group after three months,the difference between the two groups was statistically significant(P < 0.05).proved that taking nicorandil early can improve left ventricular activity and ejection fraction in non st-elevation acute myocardial infarction after percutansneous coronary intervention.3.Serious arrhythmiaThe incidence of Curtis Walker score > 3 in observation group is 4.44% and 8.89% in control group,showing statistically significant differences between the two groups(P < 0.05).4.Adverse reactions:The incidence of the adverse reactions in the observation group is 4.44% and control group is 4.44%.and patients all can endure,and the symptoms disappeared after taking the drug 2 weeks,during the observation period,two groups of patients did not show obvious function of liver and kidney dama ge and significant allergic reaction and serious drug side effects,there was no statistically significant difference between the two groups(P > 0.05).Conclusions:1.Taking nicorandi additionally based on conventional medical treatment can reduce the intractable angina of patients of Non st-elevation acute myocardial infarction after percutansneous coronary intervention.2.Taking nicorandi can effectively improve the patient’s left ventricular activity scores and Left ventricular ejection fraction(LVEF)% on patients of Non ST-elevation acute myocardial infarction after percutansneous coronary intervention.3.Taking nicorandi can effectively reduce the incidence of severe arrhythmia on patients of Non ST-elevation acute myocardial infarction after percutansneous coronary intervention.,4.Taking nicorandi proved safe and effective obviously on Non ST-elevation acute myocardial infarction after percutansneous coronary intervention.