Correlation Between Anxiety And Depression In Patients With Chronic Obstructive Pulmonary Disease Based On Cluster Analysis

Objective: We aim to investigate the incidence of anxiety and depression in patients with COPD, and to explore the relationship between anxiety and depression and COPD phenotype.Methods: HAD was investigatied objectively in 100 cases of patients with COPD, and demographic and clinical datas including sex, age, BMI, smoking index, annual acute exacerbations, complications, pulmonary function, BODE index, mMRC dyspnea score and CAT score were collected. All the above indexes were principal component analyzed in order to determine the main components and the phenotype of COPD through cluster analysis. We aim to get epidemiological characteristics in patients with COPD through calculating mobidity difference between anxiety and depression in COPD phenotype and to to know the difference between anxiety, and depression among all groups by paired test finally.Results: in this study, 100 patients with stable COPD patients anxiety scores(6.7 + 3.62), 52 patients(52%) had anxiety and 58(58%) had depression. A total of 67 cases(67%) had anxiety or depression,which 43 patients(43%) with mild anxiety or depression(score 8-10),24 cases of patients(24%) with moderate to severe anxiety or depression( more than or equal to 11 points). PAC analysis of the 11 indicators of all data, the 4 main components(characteristic value >1), all the variables can be divided into 3 categories, that is not completely independent of the variables. In all the variables the cumulative contribution rate is about 83.5%. Main components 1, including A, TS, D; principal component 2, including BODE index, mMRC sore, CAT sore, annual acute exacerbations; the main component 3 including FEV1, FVC; principal component 4 including BMI, complications. 100 cases of COPD patients in the principal component analysis of the three main components of the cluster analysis based on the tree. All the study subjects were divided into four categories by pseudo F and pseudo T2 tests. From the table, we can know that there are obvious differences between different phenotypes.(1)in relative elderly patients, the anxiety and depression index is high with moderate and severe airflow limitation and moderate dyspnea,more annual acute exacerbations and less complications;(2) in elderly patients, the anxiety and depression index is high with moderate airflow limitation, moderate dyspnea, more annual acute exacerbations and complications;(3) compared with type 2 patients, type 3 patients are relatively young patients with low anxiety and depression index,severe airflow limitation, mild dyspnea, less annual acute exacerbations and complications;(4) compared with type 1 patients,type 4 patients have low anxiety and depression,less annual acute exacerbations and complications. with independent samples t test in group1 and group 4, in addition to age indicator,the remaining indicators all have statistical significance( P<0.05),with the same consequence in Group 2 and group 3.Conclusions:(1) the number of patients with anxiety and depression symptoms was higher in in patients with COPD.(2) Index such as BODE index, mMRC sore, cat score, annual acute exacerbations,BMI and comorbidities can objectively reflect the degree of anxiety and depression in patients with COPD.(3)The heavier dyspnea, clinical symptoms, nutrition is the worse, the higher the anxiety depression score, the heavier the degree of anxiety depression.