The Correlation Research Between Cerebral Perfusion And Neuropsychology In Patients With Non-symptomatic Cerebral Anterior Circulation Vascular Stenosis

Objective:To investigate the relationships of the change of cerebral perfusion and the change of neuropsychology in patients with non-symptomatic cerebral anterior circulation vascular stenosis.Methods:Twenty-four cases with cerebral anterior circulation vascular(include internal carotid artery and middle cerebral artery)stenosis(degree>50%)were collected to process prospective study and nineteen volunteers with matched age and gender as control group.The PWI examinations were performed on 3.0T magnetic resonance and chose the following as the observing regions of interest(ROI):frontal subcortex,temporal subcortex,periventricular and centrum semiovale.The MTT values,TTP values,CBF values and CBV values were measured in the above-mentioned areas in the two groups.Calculate the ratios of illness side and mirror image for every ROI in case group and compared to normal ratios provided by control group.And the Mo CA scores,MMSE scores,CDT scores,HAMA scores and HAMD scores were measured in the two groups.Comparing analysis of age,gender,four perfusion parameters and neuropsychology scores by methods of t-test,chi-square test,non-parametric test,and analyze the relationship between neuropsychology scores and four perfusion parameters by methods of spearman rank correlation analysis.Results:(1)The age,gender,prevalence of hypertension and diabetes in case group showed no statistical significance from control group.(2)The four perfusion parameters of all observed areas in case group showed significant difference from control group(P<0.01);the MTT values and TTP values of frontal subcortex,temporal subcortex,periventricular and centrum semiovale in case group were higher than control group;and the CBF values and CBV values of frontal subcortex,temporal subcortex,periventricular and centrum semiovale in case group were lower than controlgroup.(3)The Mo CA scores,MMSE scores,HAMA scores and HAMD scores between two groups had a significant difference(P<0.05),the Mo CA scores and MMSE scores in case group were lower than control group,and HAMA scores and HAMD scores in case group were higher.No significant difference of CDT scores in two groups was found.(4)To analyze the relationship between neuropsychology scores and four perfusion parameters,the results indicated that neuropsychology changes may attribute to the changes of perfusion parameters in related regions.Correlation analysis showed that Mo CA scores were positively related with temporal subcortex CBF,CBV respectively,negatively related with centrum semiovale MTT,TTP respectively.MMSE scores were positively related with frontal subcortex CBF,CBV,temporal subcortex CBF,CBV,periventricular CBF,CBV,centrum semiovale CBF,CBV respectively,negatively related with frontal subcortex MTT,temporal subcortex MTT,TTP,periventricular MTT,TTP,centrum semiovale MTT,TTP respectively.HAMA scores were positively related with periventricular MTT,negatively related with temporal subcortex CBV.HAMD scores were positively related with periventricular MTT,centrum semiovale TTP respectively,negatively related with frontal subcortex CBF,CBV,temporal subcortex CBF,CBV,periventricular CBF,CBV,centrum semiovale CBV respectively.Conclusions:(1)The cerebral perfusion of ROI in patients with non-symptomatic cerebral anterior circulation vascular stenosis was decreased significantly,PWI can be used as an effective inspection method.(2)Patients with non-symptomatic cerebral anterior circulation vascular stenosis had cognitive impairment and emotional disorder.(3)The changes of neuropsychology in patients with non-symptomatic cerebral anterior circulation vascular stenosis was related with the cerebral perfusion of ROI.