Clinical Research Of Cardiovascular Autonomic Nerve Dysfunction In Patients With Parkinson's Disease

Objective:To investigate the cardiovascular autonomic nerve dysfunction in patients with Parkinson's disease(PD),and study the relationship of cardiovascular autonomic nerve dysfunction with age,duration,dosage of levodopa,Hoehn-Yahr stage(H-Y stage)and the unified Parkinson's disease rating scale III(UPDRS III)in PD.Methods:Fifty-one PD patients and thirty normal control were selected.All subjects were tested respectively on 24 h ambulatory blood pressure and 24 h dynamic ECG monitoring,comparative analysis of the two groups blood pressure variability(BPV)and heart rate variability(HRV)indexes,and levodopa equivalent dose(LED),H-Y stage and UPDRS III in PD patients were investigated.The related factors affecting BPV and HRV were explored.Results:The standard deviation of 24 h systolic blood pressure(24h SBPSD)?standard deviation of day systolic blood pressure(d SBPSD)?standard deviation of night systolic blood pressure(n SBPSD)of BPV in PD group were significantly higher than those in control group(all P<0.05).The standard deviation of normal R-R intervals,SDNN)?root mean square successive difference of normal R-R intervals(RMSSD)?high frequency power(HF)?low frequency power(LF)of HRV in PD group were significantly lower than those in control group(all P<0.05).BPV in PD patients was positive correlation to disease duration(P<0.05).HRV in PD patients was negative correlation to disease duration,H-Y stages,UPDRS III scores(all P<0.05).Conclusion:PD patients present the cardiovascular autonomic nerve dysfunction,performance for BPV significant rise and HRV significant decrease.Disease duration,severity of disease and motor symptoms are the related factors.