Observation Of The Effect By Repetitive Transcranial Magnetic Stimulation In The Treatment Of Primary Insomnia

Objective: Insomnia is the most common disease of sleep disorders and now the number of it is increasing year by year.In this study,the pittsburgh sleep quality index(PSQI),self-rating anxiety scale(SAS),self-rating depression scale(SDS)and Epoworth sleepiness scale(ESS)were used to evaluate the therapeutic effect of the patients who were treated by the repetitive Transcranial Magnetic Stimulation(rTMS).Methods: We totally collected 60 patients who have the disease of Primary Insomnia in the second affiliated hospital of the Second Affilicated Hospital of Dalian Medical University from 2014 to 2016 through the method of retrospective analysis.The patients were randomly divided into two groups with 30 patients in each group.rTMS treatment group had 9 patients with anxiety,7 patients with depression and 5 patients with both.Neither of the group was treated with drugs.rTMS treatment group received the treatment of rTMS ant the control group that receive the false treatment.Both groups were treated for 10 days.The PSQI was used to evaluate the treatment effect of the patients in both groups before,at the end of and 30 days after the theatment.The ESS was used to evaluate the daytime sleepness of the patients in both groups before and after the treatment.The self-rating anxiety scale and self-rating depression scale were uesed to evaluate the emotional disorders in the rTMS group.The data that was collected was indicated by the mean value±standard deviation with the SPSS 11.5 statistics software analysis,all the statistical results had statistics significance by P<0.05.Results:1.The rTMS treatment grouphad 21cases(70%) responded favorably in insomnia atthe end ofthetreatment,while control grouphad 5 cases(16.7%).The difference is statistically significant.(P<0.05)2.The rTMS treatment group had 18 cases(60%)responded favorably in daytime sleepiness at the end of the group,while control group had 4 cases(13.3%).The difference is statistically significant.(P<0.05)3.The rTMS treatment group had 3 cases(21.4%)responded favorably in anxiety and 6 cases(50%)in depression.4.The PSQI between the patients in the rTMS treatment group and control group before treatment had no statistical significance.(P>0.05)5.The PSQI in the rTMS treatment group at the end of the treatment was(11.07±2.03),30 days after the treatment was(11.90±1.79).Both values were lower than those in the control group.The difference was statistically significant(P<0.05)6.The PSQI at the end of and 30 days after the treatment of the rTMS treatment group(11.07±2.03)?(11.90±1.79)were both lower than that before the treatment(16.00±1.82).The difference was statistically significant.(P<0.05)7.The patients in the group of the rTMS group had a slightly higher PSQI(11.90±1.79)30 days after the treatment than that at the end of the treatment(11.07±2.03),but still lower than that before the treatment(16.00±1.82).8.The ESS between the patients in the rTMS treatment group and control group before treatment had no statistical significance.9.The ESS in the rTMS treatment group at the end of the treatment(3.53±1.27)was lower than that in the control group(4.97±1.52).(P<0.05)10.The SAS at the end of the treatment of the rTMS treatment group those who have anxiety(55.21±5.56)was lower before the treatment(58.57±5.02).The difference was statistically significant.(P<0.05)11.The SDS at the end of the treatment of the rTMS treatment group those who have depression(43.00±5.29)was lower before the treatment(55.92±4.81).The difference was statistically significant.(P<0.05)12.The number of early awakening in rTMS group after treatment(1.40 ± 0.93)was lower than that before treatment(2.43±1.30),The difference was statistically significant.(P<0.05)Conclusion:1.rTMS has a significant effect on the treatment of the patients with primary insomnia with no side effects and the number of early awakening is reduced.2.The quality of sleep after 30 days' treatment is better than before,but it is worse than the end of the treatment.3.rTMS can improve daytime sleepiness symptoms in patients with primary insomnia.4.rTMS can improve the emotional disorders of patients with primary insomnia symptoms.