Clinical Study Of Wendantang In Treating Insomnia With Syndrome Of Internal Disturbance Of Phlegm-Heat In Taiwan Province

ObjectivesResponse of general office of the state council announced this topic research about Traditional Chinese Medicine health service development planning requirements, based on the foundation of treatment based on syndrome differentiation, this study used WenDantang to treat insomnia with syndrome of internal disturbance of phlegm-heat and 3 main accompanied Symptoms in Taiwan Province and observed and evaluated the clinical curative effect, improved accompanyied symptoms, hoping for providing reference for Taiwan modern TCM clinical treatment of the disease.MethodsAccording to the diagnostic criteria, inclusion criteria, exclusion criteria, exclusion criteria,60 cases were collected from September 2014 to September 2015 who were all from in Daqian General Hospital of Chinese medicine clinics in Miaoli District and Dechang TCM clinic in Taiwan Province. Meanwhile, according to the situation of patients with accompanyied symptoms,60 cases were divided into 3 groups:The group of annoyance annoyed (hereafter referred to as GroupA).,The group of stuffy feeling in chest (hereafter referred to as GroupB)., The group of dreaminess (hereafter referred to as GroupC).All the cases in the study were given scientific Chinese medicine wendan Tang(A pack of Wendantang mixture composition is as follows:Banxia 4g, Shenggancao 2g, Shengjiang 2g, Zhuru 4g, Zhishi 4g, Fuling 3g, Jupi 3g, Huanglian 2g, Suanzaoren 3g.)Group A added Maidong and Zhizi on the basis of the original;Group B added Houpo, Xiangfu and Yujin on the basis of the original;Group C added Yuanzhi,Longgu and Muli on the basis of the original.After 4-week trail, we recorded the PSQI scale score (total score as well as the main indicators of sleep), TCM symptom score before and after treatment and assessed the clinical curative effect in accordance with Chinese traditional medicine new drug clinical research guiding principle.All the data analyzed with SPSS19.0 statistic softy-ware. Measurement data use (x±s) to express. The data follow normal distribution use matched T-test. The data doesn't follow normal distribution use Wilcoxon Matched-Pairs Signed-Ranks Test. X2 for count data and calculate the test statistic and the corresponding the p-values. Determined P<0.05 to be significant difference and P<0.01 to be very significant difference.Results(1)clinical efficacy:After 4 weeks of treatment,5cases were clinical cured,13 cases significantly effective,24 cases effective,18cases ineffective, total efficacy 70%. In mild cases,5cases were clinical cured, 10 cases significantly effective,12 cases effective,7 cases ineffective, total efficacy 79.41%. Effective rate of patients with moderate caseswas68.18%.4 cases of severe insomnia treatment is ineffective.3 sets of effective rate was respectively 65%,70% and 75%.(2)TCM symptoms:After 4-week treatment of observation, before and after treatment, the TCM symptoms score of Group A is:(3.33±2.04))&(2.10± 1.89);Group B is (3.23±2.12) & (1.93±1.76); Group C is (3.27±2.02) & (1.80 ±1.75). There is a very significant difference in the TCM symptoms score after treatment(P<0.01).(3)PSQI total points and the main sleep parameters:The scores of 60 patients's PSQI has a significant differences (P<0.05)before and after treatment, and PSQI average scores after treatment was more 2.52 points in average scores higher than before.while PSQI scores of 3 groups were all very significantly different (P<0.01). In terms of major indicators of sleep, sleep latency, sleeping hours, habitual sleep efficiency prompting that there were statistically significance difference between before and after treatment(P<0.01).While in Group A,the quality of sleeping, sleeping obstacle, sleeping drugs, day function showed no statistically significant difference (P>0.05). In Group B, the quality of sleeping, sleeping obstacle, sleeping drugs, day function showed statistically significant difference before and after treatment (P<0.05). In Group C, the quality of sleeping, sleeping drugs and day function showed statistically significant difference before and after treatment (P<0.05)and without significant difference in sleep disorders (P>0.05).Conclusion(1)Wendantang in treating insomnia with syndrome of internal disturbance of phlegm-heat in Taiwan Province had a obvious effect, especially the mild insomnia was best, followed by the moderate and severe insomnia was ineffective. It explain that Wendantang has certain feasibility on treating insomnia with syndrome of internal disturbance of phlegm-heat.(2)Wendantang with Maidong and Zhizi had significantly improved associated symptoms of annoyance annoyed as well as the associated symptoms of stuffy feeling in chest added with the Houpo, Xiangfu and Yujin. Wendantang with Yuanzhi, Longgu and Muli had obvious improvement in the associated symptoms of dreaminess.(3)In the process of improvement of insomnia of type phlegm-heat, Wendantang regulated the Qi, improve the sleep latency, sleeping hours and habitual sleep efficiency significantly. Although in some indicators of sleep had no significant effect, Wendatang certainly played a role in improving sleep.