| Objective The purpose of this article is to retrospectively evaluate the utility of the multiple parameters of diffusion-tensor imaging (DTI) at 3 T in differentiating central gland prostate cancer from benign prostatic hyperplasia (BPH).Materials and Methods 59 patients with the prostate carcinoma proved by ultrasound guided systemic biopsy or radical prostatectomy underwent MR scan and DTI with b value of 0 and 800s/mm2. The ADC values,FA values,RA values and VR values of prostate carcinoma were measured respectively. The differences of the FA, ADC, RA and VR values were analyzed,using ROC curve plotting obtained the area under the ROC curve of the FA, ADC, RA and VR values.Results The mean FA, ADC, RA and VR values were 0.33±0.08、(0.95±0.21)×10-3mm2/s、 0.31±0.06 and 0.88±0.04; respectively, for central gland cancers,0.28±0.11、(1.45± 0.15)×10-3mm2/s、0.28±0.05and 0.91±0.03, respectively, for stromal hyperplasia foci, and 0.22±0.04、(1.72±0.26)×10-3mm2/s、0.22±0.06 and 0.94±0.02 respectively, for glandular hyperplasia foci, and the values differed significantly except the RA values. For predicting central gland cancers, the area under the curve (Az) of ADC, FA, RA and VR values are 0.884、 0.657、0.961、0.690respectively, P<0.05.Conlusion Multiple parameters of DTI at 3 T is useful for distinguishing central gland cancers from BPH foci.Furthermore, ADC showed greater diagnostic accuracy in differentiating central gland cancers from stromal and glandular hyperplasia foci.Objective To evaluate the correlation between ADC value and FA value of diffusion tensor imaging with the Gleason score staging of prostate cancer,and to investigate the predictive value of ADC value and FA value in grading of prostate carcinoma.Materials and Methods 70 patients with the prostate carcinoma proved by ultrasound guided systemic biopsy or radical prostatectomy underwent MR scan and DTI with b value of 0 and 800 s/mm2. The ADC values and FA values of prostate carcinoma were measured. According to the result of pathology, patients of prostate cancers were classified into three groups:low grade(Gleason≤6), intermediate grade (Gleason=7)and high risk(Gleason≥8).The ADC and FA values of the three groups were analyzed by one-way ANOVA,every two groups was compared. Pearson correlative analysis test of the ADC and FA values of prostate cancer and Gleason score were used. ROC curve between Gleason≤7 and Gleason≥8 of prostate cancer was used.Results ADC values of low, intermediate and high risk prostate cancer were(0.96± 0.10)×10-3mm2/s、(0.76±0.15)×10-3mm2/s, (0.62±0.12)×10-3mm2/s respectively; FA values were 0.39±0.06、0.31±0.09、0.22±0.06, respectively. The differences among three groups of ADC and FA values were all statistically significant (p<0.05). The ADC and FA values of prostate cancer were all negatively related with Gleason score (r=-0.768, p<0.05; r=-0.662, p< 0.05),the higher the Gleasonscore was, the smaller the ADC and FA values were. The sensitivity of differentiating the low,intermediate grade and high risk cancer of ADC value was 79.5%, and the specificity was 76.9%, the accuracy was 87.1%, with the cutoff point 0.68×10-3mm2/s. The sensitivity of differentiating the low,intermediate grade and high risk cancer of FA value was 75.8%, and the specificity was 78.4%, the accuracy was 84.2%, with the cut off point 0.24.Conclusion The ADC and FA values of prostate cancer were negatively correlated with Gleason score, and they have the potential of diagnosing and forecasting the malignancy of prostate cancer. |
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