To Observe The Buyanghuanwu Decoction Clinical Effect In Treating Transient Ischemic Attack Of Qixuxueyu Syndrome

Objective:based on the clinical application and research of buyanghuanwu decoction.the study evaluates and observes such decoction to treat transient ischemic attack (transient ischemic attack, TIA) with clinical efficacy and Security;Provide a more objective basis for clinical application of TIA.Methods:using a randomized, controlled experimental design principles.the study recruited 120 qi deficiency and blood stasis TIA patients who are assigned in two group by random number method, treatment group of buyanghuanwu decoction(treatment group) and control group of the conventional treatment (control group). Both groups were based on conventional treatment which is recommend by the 2010 "China cerebrovascular disease prevention and treatment guidelines". The treatment group gives oral decoctions (5 times,3 times a day) based on control group in the same day and Antihypertensive, hypoglycemic, lipid-lowering for For patients with a history of hypertension, diabetes, hyperlipidemia and so on.During two weeks in hospital,we observe Clinical symptoms, seizure frequency, duration, ABCD2 score,,we survey secondary prevention and buyanghuanwu decoction’s taking.at the same time we observe patient’s condition change.calculate the attack number of TIA and emergence of infarction and so on. Statistical data will be collected by spss13.0Results:1. comparing general information such as sex, age, underlying disease, previous history of TIA patients and the frequency of admission of patients with TIA onset, duration, seizure type, ABCD2 risk score with Chi-square test or t test between two group. Statistical results showed no significant difference (P> 0.05) groups of patients.2. during 3-day hospitalization period, the group respectively have 20 and 12 patients with clinical symptoms of seizures under control.during 7days.there are 45 and 30 patients.after 14days,all patients’ clinical symptoms is under control. Comparison of the two groups’ qi deficiency and blood stasis syndrome scores were significantly different (P <0.05) after treatment.3. Laboratory test results suggest that the first 7 days and 14 days after treatment,MMP-9 levels drop below the level of the control group.the results was statistically significant (P<0.05). Treatment fibrinogen levels after 14 days is lower than the control group’s level, the difference was statistically significant (P<0.05)4. Treatment group and control group patients were no serious adverse reactions during the experiment and all feels well.Conclusion:1. combined with conventional treatment, Buyanghuanwu decoction can be more efficient and rapid to control TIA attack and reduce the incidence of post-stroke patients with TIA.also it has a good safety.2. after treatment of buyanghuanwu decoction,the levels of changes of hemodynamics decreased.this suggest buyanghuanwu decoction can improve the patients "condition according to effect changes of hemodynamics.