In Vitro Study Of Magnetic Drug Carrier Particles' Capture Efficiency For Implant Assisted-seeds Magnetic Drug Targeting Based On Microvessel

Magnetic drug targeting as one of the most promising method of treating cancer can increase the concentration of anticancer drug in cancer tissue and reduce the toxicity and side effects of healthy tissue. Implant assisted-seeds magnetic drug targeting(IA-MDT) can enhance the capture efficiency(CE) of magnetic drug carrier particles(MDCPs) by implanting magnetic seeds based on traditional magnetic drug targeting(MDT).The influence factors of CE for magnetic seeds and MDCPs were studied in vitro based on IA-MDT after considering the permeability effect of microvessel and blood viscosity under the scale closed to microvessel system.1) An experimental platform in vitro was built, in which porous medium material was used to simulate microvessel system, radial magnetized cylindrical permanent magnet was used as external magnetic medium, surface-modificated ferroferric oxide nonoparticles was used as seeds and MDCPs, glycerol was used to change the viscosity of seeds suspension and MDCPs suspension.2) The influences of the concentration of magnetic seeds and MDCPs, flow velocity, external magnetic field, the size of magnetic seeds and MDCPs and permeability parameter on CE were studied through experiment. The results showed that the CE of magnetic seeds and MDCPs would increase with the increases of magnetic seeds and MDCPs suspension concentration, mean radius of magnetic seeds and MDCPs and permeability parameter, and would decrease with the increases of the distance between the surface of cylindrical permanent magnet and the center of targeting area and the flow velocity. Furthermore, the CE would be generally improved when permeability effect was considered. Meanwhile, a set of parameters which could lead to an optimized CE of MDCPs was accomplished through analyzing experimental results.3) In addition, the results predicted by the theoretical model which had been established before agreed well with the experimental results. Because the experimental conditions in vitro was closed to the body environment, the results can provide valuable reference data for experiment study in vivo and the clinical application of IA-MDT in the future.