| Objective To master weather the relationship exists between the maternal sociodemographic factors and the hyperbilirubinemia of full term infant, Learn neonatal indirect hyperbilirubinemia Incidence and risk factors of Shaodong area;To research the effectiveness and safety of, analyze the mechanism of, and know the relation about the values of TCB and T-Bi L of the hyperbilirubinemia of full term infant treated with tompound glycyrrhizin;provide evidence for the prevention and treatment of neonatal hyperbilirubinemia.Methods Collected in July 2013- July 2014 in People’s Hospital Pediatrics of Shaodong County neonatal hospitalization and neonatal indirect hyperbilirubinemia in children 193 cases,They were randomly divided into control group(n = 102) and observation group(n = 91),Comparable between the two groups weight,gestational age,serum total bilirubin level,gender,age, etiology and other general information,Calculation the constituent ratio of 193 cases of children with risk factors(perinatal factors, infectious factors, factors in breast milk, ABO hemolytic).The control group received conventional treatment with light therapy,Observation group was based on the use of compound glycyrrhizin intravenous injection, 2ml / kg / time, 1 time per day for seven days.After the treatment, the two groups judged to compare levels of serum bilirubin levels and decrease the incidence of adverse reactions and jaundice time.Using linear correlation analysis were collected before and after treatment correlated fasting blood serum total bilirubin level measured value and transcutaneous bilirubin values were analyzed.Regression analysis produced female sociodemographic characteristics(age, occupation, education level, place of residence, economic status, health insurance status, prenatal care institutions and knowledge of prenatal care) and the incidence of neonatal indirect hyperbilirubinemia using multivariate unconditional logistic correlation and risk factors.Results1.Delivery mother sociodemographic characteristics of single factor and neonatal indirect hyperbilirubinemia an association between maternal farmers living in rural areas, older, low educational level, the relative lack of knowledge of prenatal care population, born newborn children the opportunity to increase the incidence of high incidence, the difference between groups was statistically significant(P <0.01).2.By non-conditional logistic regression analysis, production mother sociodemographic characteristics factor in age, education level, knowledge of prenatal care is a risk factor neonatal indirect hyperbilirubinemia.3.The most common risk factors for indirect hyperbilirubinemia in term newborns for production factors and infectious factors around, accounting for 45.08% and 21.76%.4.Two groups of children weight, gestational age, serum total bilirubin level, gender, age, etiology and other general information, the difference was not statistically significant(P> 0.05).5.The control group, the observation group total effective rate were 74.51%, 97.80%, the two groups, the difference was statistically significant(χ2=24.56, P<0.01).6.After the observation group serum total bilirubin levels were significantly lower than the control group(t = 17.99, P <0.05), was observed in serum total bilirubin values than the control group increased(t = 16.71, P <0.05), was observed 3,5,7 days after treatment group decreased serum total bilirubin was significantly higher than the control group(P <0.01), the observation group after treatment perinatal factors, infectious factors, breastfeeding factors, ABO hemolysis, other factors related to serum total bilirubin value was higher(P <0.01).7.Jaundice time shorter observation group than the control group(t = 4.38, P <0.05).8.The incidence of adverse reactions of he control group and observed group were respectively10.78%,9.89%, respectively,the difference was not statistically significant(χ2=2.41, P>0.05).9.With positive correlation between the transcutaneous bilirubin and the venous blood bilirubin of 193 cases of neonatal hyperbilirubinemia diagnosed(r=0.916,P<0.01). Conclusions1.Delivery mother sociodemographic characteristics and the incidence of indirect hyperbilirubinemia in term newborns there is a correlation,Age, education level, knowledge of prenatal care were the risk factors of neonatal indirect hyperbilirubinemia.2.Compound glycyrrhizin injection in treating indirect hyperbilirubinemia in term newborns is effective, it can significantly reduce serum total bilirubin, jaundice shorter time, and fewer adverse reactions, can be used as the clinical treatment of full-term newborns one of the effective drugs with indirect hyperbilirubinemia. |
PDF Full Text Request