Clinical Study Of Shugan Jianpi Xiaoying Decoction In The Treatment Of Hashimoto’s Thyroiditis

Objective:This study was designed to collect clinical history data observed Shuganjianpi Xiaoying Treatment of subclinical hypothyroidism period(referred to as subclinical hypothyroidism) the clinical efficacy of liver and spleen deficiency Hashimoto’s thyroiditis, study for patients with clinical symptoms and signs improvement in levels of thyroid hormones, thyroid autoantibodies, to explore the mechanism for the medical treatment of Hashimoto’s thyroiditis provide effective ideas and methods.Methods: Randomized controlled method, selected from clinical met the inclusion criteria of subclinical hypothyroidism in patients with Hashimoto’s thyroiditis liver and spleen deficiency 60 cases were randomly divided into 2 groups, the treatment group and the control group(30 cases). The control group received the Merck company levothyroxine sodium tablets, 25 ug. The treatment group received Shuganjianpi Xiaoying party on this basis, a day, morning and evening, warm clothes and a half hours after a meal, for 4 weeks as a course of treatment, a total of 2 courses. The two groups before and after treatment in patients with clinical symptoms and signs, serum thyroid hormone levels, thyroid autoantibodies changes, while recording adverse drug reactions, and related data using SPSS17.0 statistical software for statistical analysis.Results:1. The total effect of the analysis: The total effective rate was 100% in the control group, the total effective rate of 87%, by t test, P <0.01, significant difference between the two groups, the treatment group than the control group; 2 TCM. symptom score analysis: before and after treatment in the two groups, P <0.01, significant difference, indicating that the two groups could reduce the TCM symptom scores; comparison between the two groups after treatment, P <0.01, significant difference, and the treatment group was significantly lower than the control group; 3 thyroid function analysis:. FT3, FT4 compare before and after treatment in the two groups, all P> 0.05, not statistically significant, indicating that FT3, FT4 did not change significantly after treatment; after treatment comparison between the two groups, all P> 0.05, no statistical significance; comparative TSH before and after treatment in the two groups, all P <0.01, significant difference, indicating that the two groups could reduce TSH levels; comparison between the two groups after treatment, all P <0.01, significantly different, and the treatment group TSH levels were significantly lower than the control group; 4 thyroid autoantibodies analysis: comparison in the two groups before and after treatment, all P <0.01, significant difference, indicating that in both groups can reduce TGAb, TPOAb; comparison between the two groups after treatment, P <0.01, significant difference between the treatment group TGAb, TPOAb was significantly lower than the control group.Conclusion:Shuganjianpi Xiaoying party euthyrox combined with low-dose treatment of subclinical hypothyroidism on liver and spleen deficiency Hashimoto’s thyroiditis have significant clinical efficacy, and can improve the clinical symptoms, improve thyroid function, reduced levels of thyroid autoantibodies adverse reactions, the process does not appear, relatively safe.