Research On Yiqi Huoxue Huatan Fang Of Coronary Plaque Instability And Its Effects On Serum TNF-??IL-6?hs-CRP Effects

Object: Discussion on the anti-inflammatory effect of stabilizing plaque Yiqi Huoxue Huatan Fang Duiguan veins unstable plaque by studying the clinical application of serum on Yiqi Huoxue Huatan Fang of traditional Chinese medicine Qi and phlegm and blood stasis in patients with unstable angina type TNF-?,IL-6,hs-CRP and other inflammatory factors of influence.Methods: Using clinical observation methods to develop observation and analysis of relevant clinical observation table,Select October 2014-October 2015 in the outpatient and inpatient Geriatrics Cardiology,the First Affiliated Hospital of Henan University of Chinese Medicine confired TCM diagnosis: Chest(Qi and Phlegm Blood stasis syndrome);Western diagnosis: unstable angina patients,a total of 60 cases.The patients were randomly divided into two groups,the control group received conventional anti-platelet aggregation,anticoagulant,anti-ischemic drugs and atorvastatin calcium tablets 20mg/d treatment.In the treatment group therapy based on the use complex prescription.Both groups before treatment and after 24 weeks of treatment were measured serum lipid levels and inflammatory cytokines TNF-?,IL-6,hs-CRP level,Multi-slice spiral CT coronary plaque average CT value,the minimum CT value plaque and plaque volume situation.Through statistical package SPSS18.0 to establish a database for data management and analysis the final result.Results: 1.Detected no significant difference in two groups of indicators before each treatment(P>0.05);2.After treatment,the efficacy of the two groups of Chinese and Western medicine,blood lipids,TNF-?,IL-6,hs-CRP,coronary plaque index compared with before treatment,with a statistically significant difference(P<0.05);3.After treatment,the observation group and the control group:(1)observation group angina symptoms 16 cases markedly effective in 13 cases,1 case,the total effective rate was 96.67% in the control group,10 cases markedly effective in 12 cases,8 cases,the total efficiency of 73.33%;the symptom score improve aspects of the observation group 79.32%,53.28% in the control group;there were significant differences(P<0.05),to improve the observation group than the control group.Clinical aspects electrocardiogram showed no significant difference between the two groups(P>0.05);two groups were not there during hospitalization of patients worsening angina symptoms.(2)lipids: the observation group TC,TG,LDL-C was significantly lower than the control group,HDL-C was significantly higher,and has a significant difference(P<0.05);(3)serum inflammatory factors:the observation group TNF-?,IL-6,hs-CRP levels were significantly lower than the control group,and has a significant difference(P<0.05);(4)multi-slice spiral coronary CT:The average CT value,a minimum CT values:compare the group after treatment than before treatment significantly increased the observation group plaque(P<0.05),the control group only observed an increased trend,but there is no significant difference(P>0.05);between the two groups: two groups of average CT value plaque plaque minimum CT values were significantly different after treatment was significantly increased(P<0.05)in the observation group than the control group.Plaque volume:the two groups before and after treatment reduced visibility,but did not reach a significant level(P>0.05).Conclusion: Yiqi Huoxue Huatan Fangcombined with atorvastatin can reduce the serum of patients with unstable angina pectoris TNF-?,IL-6,hs-CRP and other inflammatory cytokines;can improve the stability of coronary atherosclerotic plaques;more excellent play to anti-inflammatory immune response;can significantly relieve symptoms of myocardial ischemia in patients with unstable angina.Both have a synergistic therapeutic effect,for the clinical treatment of unstable plaque,lowering in patients with unstable angina incidence of cardiovascular events provide a more reliable clinical efficacy.