The Study On The Correlation Between Serum Sodium And Kidney Injury、Mortality、Serum Creatinine Level In Patients With Hypernatremia

Part 1Objective This study is going to analysis the correlation between the level of serum sodium and mortality、kidney injury, to investigate the prognosis of hypernatremia.Methods105 patients were admitted according to the inclusion and exclusion criteria among the patients with hypernatremia admitted to the intesive care unit(ICU) in First Affiliated Hospital of Jinan University from January 2014 to January 2016. Collect the general clinical data, serum sodium and serum creatinine level of these patients to conduct a retrospective study. Statistical analysis is conducted by SPSS for Windows Ver.19.0 statistical software.Results1. General comparison of the moderate and severe patients with hypernatremia including age,sex, the sodium and creatinine value admitted to ICU, the primary disease has no significant difference(P >0.05).2. Severe(89.74%) hypernatremia patients have higher mortality than moderate patients(62.96%),and it has significant difference(P=0.009).3. The duration of Severe hypernatremia [8(5,12.75)days] is significant prolonged compared with moderate patients [4(3.5,7)days](P<0.05).4. The severe hypernatremia patients have a higher incidence of AKI than moderate patients, and it has significant difference(P=0.041).Conclusions The higher sodium get, the longer the duration of high sodium, the higher incidence of AKI,the higher the mortality rate.Part 2Objective This study is going to analysis the correlation between the level of serum sodium and serum creatinine, to investigate the relationship between hypernatremia and acute renal dysfunction.Methods There were 60 patients as research object,which were excluded with chronic kidney disease,mannitol and blood purification on the basis of research object in Part 1. Collect the general clinical data, serum sodium serum creatinine level and osmotic pressure of these patients to conduct a retrospective study. Statistical analysis is conducted by SPSS for Windows Ver.19.0statistical software.Results1. The sodium and creatinine at the stage of highest sodium were higher than that admitted to ICU(P<0.05).2. There was no difference in sodium between the severe and moderate groups when admitted to ICU, but has a significant difference in creatinine value(P<0.05). Serum sodium and creatinine in the severe group are higher than moderate group and both have significant difference at the stage of highest sodium.3.Serum sodium and osmotic pressure were selected into the multiple linear regression equation while creatinine value was dependent variable. The coefficient of determination(R2) was 0.322;the calibration coefficient of determination(R2adj) was 0.307, the fitting equation is Y=-996.904+2.802(serum sodium)+2.046(osmotic pressure)。Serum sodium and osmotic pressure were positively associated with creatinine level.Conclusions There was a linear positive correlation between creatinine and serum sodium 、 osmotic pressure. The development of hypernatremia and acute renal dysfunction were probably promoted by each other.