Risk Factors Of Central Lymph Node Metastasis In Unifocal Papillary Thyroid Microcarcinoma

?Objective?Analyze related factors of central lymph node metastasis in unifocal papillary thyroid microcarcinoma and screen out the risk factors to provide some clinical reference value.?Method?189 cases were acquired from general surgical of Fujian Provincial Hospital from January 2013 to December 2015 undergoing the first surgical treatment with confirmed PTMC by paraffin pathology, including 134 unifocal PTMC and 55 multifocal PTMC. Their basic clinical information, ultrasound, serum, pathology,BRAF gene and immunohistochemistry were retrospectively analyzed and input into SPSS20.0 for statistics. Use chi-square test and logistic regression methods to analyze the relations between gender, age, tumor location, microcalcification,aspect ratio>1, TSH, tumor size, capsular invasion, Hashimoto, BRAF mutation,CK19, Galectin-3, MC and central lymph node metastasis in unifocal PTMC to screen out the risk factors.?Result?1?Male gender and tumor size>6mm were independent risk factors of central lymph node metastasis in unifocal PTMC patients(P<0.05). The risk of male was3.469 times that of female in central lymph node metastasis for unifocal PTMC patients; The risk of tumor size>6mm was 2.492 times that of ?6mm in central lymph node metastasis for unifocal PTMC patients; There was no correlation between age, tumor location, microcalcification, aspect ratio>1, TSH, capsular invasion, Hashimoto, BRAF mutation, CK19, Galectin-3, MC and central lymph node metastasis in unifocal PTMC patients(p>0.05).2?The rate of central lymph node metastasis and the positive expression rateof BRAF gene mutation in uinfocal PTMC patients were significantly lower than that in multifocal PTMC patients(P<0.05)(the positive rate of CLNM was 30.6%and the positive rate of BRAF mutation was 71.6% in unifocal PTMC; the positive rate of CLNM was 67.3% and the positive rate of BRAF mutation was 89.1% in multifocal PTMC); however, there was no significant difference between unifocal PTMC patients and multifocal PTMC patients in other potential risk factors, such as gender, age, TSH, Hashimoto, capsular invasion, CK19, MC, and Galectin-3(P>0.05).?Conclusion?1?Male gender is the risk factor of central lymph node metastasis in unifocal PTMC patients.2?Tumor size>6mm is the risk factor of central lymph node metastasis in unifocal PTMC patients.3?The rate of central lymph node metastasis in uinfocal PTMC patients are significantly lower than that in multifocal PTMC patients.4?The positive expression rate of BRAF gene mutation in uinfocal PTMC patients are significantly lower than that in multifocal PTMC patients.