Correlation Of Radiological Characteristics And Pathological Classification In Pulmonary Invasive Adenocarcinoma With EGFR Mutation

Objective:To investigate and discuss the correlation of radiologial characteristics and pathological classification in primary invasive adenocarcinoma with epidermal grow factor receptor(EGFR) mutation.Methods:The clinical data of 84 patients who diagnosed with Pulmonary invasive adenocarcinoma by pathology and further had EGFR Mutation between june 2013 to december 2014 were retrospectively collected and compared.Then analyze the correlation of radiological characteristics and pathological classification in pulmonary invasive adenocarcinoma with EGFR mutation.Results:The total mutation rate of EGFR was 70.2%,the mutation rate was 82.8% in women and 61.2% in men with statistical difference(P<0.05);the mutation rate was 82.8% in pulmonary nodules that containing GGO component in CT images,and the rate was 59.4% in pulmonary solid nodules,both difference has statistics significance(P<0.05);between pathological classification:the mutation was 71.7% in acinar perdominant adenocarcinoma,was 83.3% in lepidic predominant adenocarcinoma,was 60.0% in papillary predominant adenocarcinoma,was 100% in micorpapillary predominant adenocarcinoma,was 50.0% in solid predominant adenocarcinoma with mucin production,the mutation rate was not different between groups;EGFR mutation site is unrelated with sex and GGO,EGFR mutation site was not different between acinar perdominant adenocarcinoma and lepidic predominant adenocarcinoma.Conclusion:EGFR mutation is more prevalent in femal and pulmonary nodules that containing GGO component,and is no relate to the pathological classification;EGFR mutation site is unrelated with sex and GGO,EGFR mutation site was not different between acinar perdominant adenocarcinoma and lepidic predominant adenocarcinoma.