| Simulation of bone growth is a multi-discilinary research field, which involves mechanics analysis, finite element analysis and orthopedics relevant knowledge. It plays an important role in researching cartilage ossification involving cartilage-related diseases for the bone growth process. It aims to provide reference value for clinical medicine. However, researches which consider mechanical factors influence bone growth process are not yet ripe.This study is to describe cartilage ossification and bone reconstruction medical phenomenon. The results can verify the correctness of the cartilage ossification program and the rationality of the way how to apply the load. This study operates CT images which are provided by the Royal Melbourne Children’s Hospital, and obtain two-dimensional and three-dimensional models of the proximal femur which can be operated in ABAQUS. Finite element method and bone growth formula are combined together to simulate the ossification process. The femoral head area is divided into five different loading areas. Five kinds of load are applied on the model intermittently, and the load data comes from experimental measurement. This paper compares with the critical maturation index by calculating maturation index in every single finite element. If the calculation result is greater than the critical value, then the cartilage convert to new bone and local regions which are transformed into bone are remodeled. The local regions are remodeled according to an algorithm which can change material properties, or the element still keep cartilage statement. The simulation images are consistent with the bibliography and the medical images. The 2D femoral model simulation results show the development of the secondary ossification center. The outer diameter of femoral shaft has achieved a maximum density because of bone form. The central portion of the shaft is indicated a minimum density because of bone apposition. The ossification originally happen at the edge of growth plate of 3D femoral model then the trend expands.Innovation of this paper is reflected in the research methods. The paper uses the proximal femur model clinical images which have actual material properties, and using intermittent load, the load from the experimental data, Combing with the actual research models and experimental data. The simulation result is reasonable, so it provides a reference value to quantitative research biomechanical bone growth. |