Retrospective Study On Effect Of Different Treatments Of Immune Thrombocytopenia

Objective: This study aimed to investigate responses of different clinical treatments of immune thrombocytopenia(ITP).Methods: According to established inclusion and exclusion criteria, clinical data were collected. Responses to different clinical treatments of ITP were compared by different groups which were divided by therapeutic efficacy to three groups including complete response(CR), partial response(PR) and no response(N R).Results: 86 patients(8 male, 78 female, median age 41) were included in the study. Hemorrhagic manifestations were observed in 57 patients(66.3%); skin petechia and ecchymosis occured more commonly(43.2%); 1 patient(1.2%) occurred intracranial hemorrhage. O f the 86 patients, 46(53.5%) achieved complete response(CR) and 16(18.6%) achieved partial response(PR) and 24(27.9%) no response(NR), and the overall response(OR, OR=C R+NR) rate was 72.1%. In different combination treatments, the difference of effect between low dose steroid(Dexamethasone dose ?5mg/day) with thrombopoietin(TPO)(OR rate 71.43%, NR rate 28.57%) and large dose steroid(Dexamethasone dose >5mg/day) with TPO(OR rate 83.33%, NR rate 16.67%) was not significant(P>0.05). The overall response(OR) rate of interleukin-11(IL-11) was 71.4%. There was significant difference about responses of reticulocyte count in ITP after treatments in C R and NR(P<0.05).Conclusion: Low dose steroid(Dexamethasone dose ?5mg/day) with TPO is recommended. IL-11 shows well efficacy during ITP treatments. To some extent, reticulocyte count may be able to reflect the proliferative degrees of bone marrow and the responses to treatments, and has a relation with platelet count increasing.