Therapeutic Targeting Of Mitochondria In Alzheimer's Diseases

Alzheimer's disease(AD) is the most common neurodegenerative diseases characterized as memory and cognitive decline, affecting millions of people around the world. Nowadays the cause of AD remains unclear and there still lacks effective clinical treatments. Mitochondria are the energy factories of cells, and a growing number of studies have confirmed that mitochondrial dysfunction plays a crucial role in the aging process including abnormal respiratory chain dysfunction induced by oxidative stress, mitochondrial dynamics defects, loss of mitochondrial biogenesis, mt DNA mutations, etc. Mitochondria can be used as drug therapy targets by protecting and improving mitochondrial function to achieve delay or improvement of clinical symptoms. This article elucidates the main performance of mitochondrial dysfunction in AD and introduces a series of drugs and techniques targeting mitochondrial therapy in considerable prospect, which provides a new way of thinking for Alzheimer's disease treatment.