The Study Of Brain Structure And Brain Perfusion In Patient With First-episode Major Depressive Disorder With VBM And PCASL

Objective: Using voxel-based morphometry(VBM) and pseudo-continuous arterial spin labeling(p CASL) technology to detect the regional differences between the first-episode major depressive disorder and healthy controls in brain volume size and cerebral blood flow, discusses the abnormal areas of brain structures and brain function in the first-episode major depressive disorder, as well as the relationship between the changes of brain structure and brain functional, to provide clues for the pathological mechanisms of depression。Methods: Twelve participants diagnosed with first-episode major depressive disorder and Twelve healthy controls who were matched in ages、gender and education level were recruited, all the subjects accepted head MRI scans with 3D-T1WI-FFE sequence for brain structures imaging, and pseudo-continuous arterial spin labeling sequence(p CASL) for brain perfusion imaging, VBM was used to evaluate the whole brain characteristics of morphology changes, regional cerebral blood flow was used to assess the the regional brain characteristics of funtional changes. SPM8 and REST software were applied respectively to preprocessing the imagings and making statistical analysis.VBM and r CBF dates comparation between the two groups were made by double samples t-test,age and gender as covariate, the cluster size≥30 voxels, P<0.05,the difference was statistically significant.General datas(age, education degeree) comparation between the two groups were made by double samples t-tes with SPSS 19.0 statistical software, P < 0.05, the difference was statistically significant.Result: 1. VBM comparison between the two groups:(1) compared to healthy controls, the left middle frontal gray matter volume was reduced significantly in the first-episode major depressive disorder group(P < 0.05, the cluster size ≥30 voxels,FDR correction);(2) the difference between the two groups of whitematter volume did not significant. 2. r CBF comparison between the two groups:(1) compared to healthy controls, the left temporal lobe、left frontal lobe、left cingulate cortex and the left precentral gyrus blood perfusion were significantly lower in the first-episode major depressive disorder group(P<0.05, the cluster size≥30voxels,FDR correction);(2) compared to healthy controls,the right cerebellum、the right side of the thalamus、right frontal lobe、right anterior cingulate and left insular lobe cerebral blood flow perfusion were significantly increased in the first-episode major depressive disorder group(P < 0.05, the cluster size ≥30 voxels,FDR correction).Conclusion: 1. The left middle frontal gray matter volume was reduced in the first-episode major depressive disorder patient. 2. There are both increased and reduced regions of cerebral blood flow in MDD patients. the reduced regions include: the left temporal lobe、left frontal lobe、left cingulate cortex and the left precentral gyrus; the increased regions include:the right cerebellum、the right side of the thalamus、right frontal lobe、right anterior cingulated. ASL can noninvasively reveal the abnormal regions of cerebral blood flow perfusion in MDD patients. 3. Changes of cerebral blood flow and brain volume co-occur in patients with MDD,but there is no significant associations between the changes of brain volume and r CBF in patients with MDD.