| Objective:This study observes the impact of space-time pattern characteristics of ERP-LPP on rTMS in the treatment of PSPD patients and initially discusses the impact of emotion on PSPD and possible efficacy mechanism of rTMS.Methods:1.Randomly selected 15 PSPD patients included into experimental group and 15 normal subjects included into control group, evaluated the symptom scores and space-time pattern characteristics of ERP-LPP of two groups and observed differences betw-een PSPD patients and normal subjects.2.Experimental group was accepted 15 rTMS treatment and observed changes of symptom scores and ERP-LPP 3 weeks after treament.Results:1.Compared with three types of affective pictures in control group:amplitude of positive pictures was relatively higher,and had moderate excitatory with temporal and occipital lobe,and lightly moved to left cortex of temporal lobe;there was no space-time pattern characteristics with neutral pictures;amplitude of negative pictures was relatively higher.and had moderate-high excitatory with middle and right cortex of frontal,partial,temporal and occipital lobe.2.Compared with three types of affective pictures in experimental group:amplitu-de of positive pictures decreased,and had moderate excitatory with middle cortex of frontal,partial,temporal and occipital lobe;there was no space-time pattern characteris-tics with neutral pictures;amplitude of negative pictures increased,and had high excit-atory with middle and left cortex of frontal,partial,temporal and occipital lobe.3.Compared with control group,amplitude of positive pictures in experimental group was higher in F3,F4,C4,Fz.Cz points(middle and right cortex of frontal and parietal lobe) and there was statistical difference(p<0.05);there was no statistical difference with amplitude of neutral pictures(p>0.05);amplitude of negative pictures was higher in F3,C3 points(left cortex of frontal and parietal lobe) and there was statistical difference(p<0.05).4.Compared with control group,symptom scores in experimental group were lower and there was statistical difference after treatment (p<0.05).5.Compared with three types of affective pictures in experimental group after treatment:amplitude of positive pictures increased,and had high excitatory with mid-dle and left cortex of frontal,partial and temporal lobe;there was no space-time pattern characteristics with neutral pictures;amplitude of negative pictures decreased,and had low-moderate excitatory with middle and right cortex of frontal and partial lobe.6.Compared with pre-treatment,amplitude of positive pictures in experimental group after treatment was higher in F3,C3,Fz,Cz points((left cortex of frontal and parietal lobe) and there was statistical difference(p<0.05);there was no statistical difference with amplitude of neutral pictures(p>0.05);amplitude of negative pictures was lower in F3,F4,C3,C4,Fz,Cz points(frontal and parietal lobe)and there was statistical difference(p<0.05).7.Compared with control group,amplitude of positive pictures in experimental group after treatment was higher in F3,F4,C3,C4,Fz.Cz points(frontal and parietal lobe)and there was statistical difference(p<0.05);there was no statistical difference with amplitude of neutral pictures(p>0.05);amplitude of negative pictures was lower in F3,F4,C3.C4,Fz,Cz points (frontal and parietal lobe)and there was no statistical difference(p>0.05).Conclusion:1.The space-time pattern characteristics of ERP-LPP with normal subjects are to perceive emotion with occipital and parietal lobe,regulate and control emotion with frontal lobe,and the left frontal lobe facilitates to positive emotion,the right frontal lobe facilitates to negative emotion.2.The space-time pattern characteristics of ERP-LPP with PSPD patients are to perceive emotion with occipital and parietal cortex,but the ability with frontal lobe to regulate and control emotion is impaired,and the left frontal lobe facilitates to negative emotion,the right frontal lobe facilitates to positive emotion,which was possible one of causes about emotion impacting on PSPD.3.rTMS therapy can improve the ability of regulate and control the positive sentiment with PSPD patients, inhibit the interference of negative emotion,recover the excited state of frontal cortex and achieve analgesic effect. |
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