An Analysis Of The Effect Of Hypocalcemia On The Prognosis Of Patients With Intracerebral Hemorrhage

ObjectiveTo analyze the related factors of prognosis on patients with intracerebral hemorrhage,and explore the effect ofhypocalcemia on the prognosis of patients with intracerebral hemorrhage by prospective study.MethodsA total of 410 patients consecutively admitted within 12 hours after intracerebral hemorrhage onset was divided intogroups of low,normal and high levelsbased on admission serum calcium.Baseline characteristics of patients includingage,sex,Glasgow coma score(GCS),hematoma volume,etc were collected and analyzed.A follow-upwas performed after 6 months.Final outcome was assessed using Glasgow outcome score(GOS)with ascore>3 regarded as favourable prognosis,ascore<3 regarded as unfavourable prognosis.Results410 patients were enrolled during the study period.220 cases were men and 190 were women.Patients age ranged from 32 to 80 years(mean 63.8±12.2 years).Baseline calcium levels were collapsed into groups of low(<2.25mmol/L),normal(2.25mmol/L-2.75mmol/L)and high(>2.75mmol/L)levels.45 cases were presented in groups of low,330 cases in group of nomal,34 cases in group of high.Lowserum calcium gourp had lower GCS,bigger hematoma volume,higher rate of operation,higher rate of rebleeding,more unfavourable prognosis than other 2 groups.On multivariateanalysis,GCSscores,hematoma volume,rebleeding,hypocalcemia were the risk factors of prognosis on patients with intracerebral hemorrhage.Multivariable Logistic regression analysis showed that there were fewer patients with favourable prognosis in lowserum calcium gourp than normal serum calcium gourp after adjusting for potential confounders(P<0.05),(Oddsratio,3.01;95%confidenceinterval,1.06-6.12).ConclusionsHypocalcemia is independentrisk factors of prognosis of patients with intracerebral hemorrhage.The clinical benefitand therapeutic time window for hypocalcemia(?)modification remain unknown,and further studies of theseissues will be required.