Research Of Treatment For Patients With Diminished Ovarian Reserve Of Both Yin And Yang Deficiency By Using Meridian Row Acupuncture Method In Different Phases

Objective:This study examines the clinical efficacy of ovarian reservedysfunction by using meridian row acupuncture method on premenstrual group and postmenstrual group,aiming to explore the optimal period of acupuncture treatment of this disease,and to provide a more effective and safer treatment for clinical practice.Methods:70 patients with diminished ovarian reserve caused by yin and yang deficiency were randomly divided into postmenstrual group and premenstrual group,with 35 cases in each group.Two groups were applied to the same meridian row acupuncture method,and Zusanli,Xuehai,Sanyinjiao,Taichong,Neiguan,Shenmen points.To the patients with menstrual cycle,the postmenstrual group starts from the first day after the end of menstruation and the premenstrual group starts from 10 days before the onset of menstruation.Two groups were given acupuncture 10 days for a course of treatment,total courses in 6 months.To the patients without menstrual cycle,acupuncture from their first visit,10 days for a course of treatment,regular treatment 10 days per month,total courses in 6 months.The menstruation,TCM symptom and BREF scores and serum sex hormones were respectively compared in the period of pre-treatment,the first three months of treatment,six months of treatment and six months after treatment.Results:1.The total efficiency:After 6 months of treatment,the total effective rate of premenstrual group was 85.71%,88.57%for the postmenstrual group;good improvement rate:premenstrual group and postmenstrual group were both71.43%.There was no difference between the two groups overall efficiency（P>0.05）.Indicating that there was no difference about the clinical efficacy between taking acupuncture before or after the menstruation.2.Clinical symptom scores:Two groups showed significantly improved after 6 months treatment comparing with the period of pre-treatment and 3months treatment（P<0.01）,no significant difference between the two groups（P>0.05）.Stopping treatment six months,two groups showed significantly improved compared with the period of pre-treatment（P<0.01）,no significant difference compared with 6 months（P>0.05）,and also between the two groups（P>0.05）.3.BREF scores:Two groups showed significantly improved after 6 months treatment（P<0.01）,but no significant difference compared between the two groups（P>0.05）.Stopping treatment six months,two groups showed significantly improved compared with the period of pre-treatment（P<0.01）,but there was no significant difference compared with 6 months treatment（P>0.05）,and also between the two groups（P>0.05）.4.Menstruation:（1）Days of menstrual cycles:Two groups showed significantly improved after 6 months treatment comparing with the period of pre-treatment and 3months treatment（P<0.01）,no significant difference between the two groups（P>0.05）.Stopping treatment six months,two groups showed significantly improved compared with the period of pre-treatment（P<0.01）,no significant difference compared with 6 months（P>0.05）,and also between the two groups（P>0.05）.（2）Menstrual days:Two groups showed significantly improved after 6months treatment comparing with the period of pre-treatment and 3 months treatment（P<0.01）,and there was significant difference between the two groups（P<0.01）.Stopping treatment six months,two groups showedsignificantly improved compared with the period of pre-treatment（P<0.01）,no significant difference compared with 6 months（P>0.05）,but there were obvious differences between groups（P<0.01）.5.Serum hormone levels:E₂and FSH levels in Two groups showedsignificantly improved after 6 months treatment comparing with the period of pre-treatment and 3 months treatment（P<0.01）.LH level in the group ofpremenstrua showed significantly improved compared with the period ofpre-treatment（P<0.01）,and also improved compared with 3 months treatment（P<0.05）.Stopping treatment six months,two groups showed significantly improved compared with the period of pre-treatment（P<0.01）,no significant difference compared with 6 months（P>0.05）,but between groups,E2 level in the group of postmenstrua showed significantly improved after 6 monthstreatment and stopped treatment six months than the group of premenstrua,both of the FSH and LH levels showed differences between groups（P<0.05）.Conclusion:（1）By using meridian row acupuncture method in the treatment of decreased ovarian reserve can achieve an ideal result either during the premenstrua or postmenstrua,improve clinical symptoms and quality of living,adjust the menstrual cycle,reduce serum E₂,FSH,LH levels,and stable long-termefficacy.（2）There were obviously advantages of doctoring during postmenstrua on increasing the menstrual days and decreasing the serum E₂,FSH,LH levels.The mechanism may be that doctoring during postmenstrua could betterregulating the hypothalamic-pituitary-ovarian reproductive axis function,potentiate the negative feedback from E₂to hypothalamic and pituitary,reduce follicle consumption,improve the follicular development and endometrial growth.