The Study On The Process Of Three-Dimensional Gel Printing Based On Bingham Fluid Support

Three-dimensional printing technology,also known as Additive Manufacturing,rose in the last century 90's.And it has been widely used in the automotive,construction,medical and other fields.3D printing is attracting more and more attention because of its advantages such as quick response,convenient operation,personalized customization and precise reproduction.Over the past few decades,the road of biomaterials three-dimensional printing has evolved from the rapid prototyping of medical aids for development and research toward manufacturing private and custom-made medical equipment.Three-dimensional gel printing as a three-dimensional biological material printing,is making the biological material in accordance with the law of deposition form three-dimensional entities.If the biological material mixed with cells,and then to be created entities using the three-dimensional printing technology,the organ model with biological activity can be obtained with after further culture.Therefore,it is of great significance to study and improve the gel printing process and realize the precision control of the three-dimensional printing in the field of biological applications.In this article,the printing parameters and path of the gel were optimized in order to improve the printing precision based on the analysis of the printability of sodium alginate gel.Further,a gel-printing process based on gelatin support material is proposed.The performance and preparation method of gelatin as a support was explored.The printing process parameters of the gel in the support were improved,and the pressure parameters were analyzed theoretically.In addition,this article also carried out a series of comparative experiments to study the mechanical properties of the gel according to different factors.Finally,the gelatin-supported printing process was used to print the physical structure,spatial structure,bifurcation structure and Y-type structure.The potential application of this process in medical field was explored.The main work of this article is as follows:(1)Exploration of gel bio-print parameter settings and the printing process.Including the printing process platform design and printing parameters experiment.Reasonable setting of printing parameters and path optimization in point gel structure,line gel structure,and solid gel structure forming.The aim is to obtain better dimensional accuracy and overall degree.Finally,the biocompatibility of the gel and the harmlessness of the printing process were verified by cell printing experiments.(2)Analyzing the physical properties of Bingham fluid.By establishing the physical model of Bingham fluid in gel three-dimensional printing,the mathematical relationship between Bingham fluid and printing parameters is explored.The printing performance of the supporting material is analyzed theoretically.(3)Exploration and optimization of gel printing technology in gelatin support.Study on the performance of supporting materials and preparation process.Optimization the gel printing parameters and process based on the original printing platform,to achieve precision control and complex gel structure of the printing method.The pressure drop of the gel material in the long nozzle is analyzed theoretically to solve the problem of nozzle length and pressure parameter selection.(4)Printing different types of structure using gelatin-based printing process to explore its potential applications in the field of learning.Printing 3D human body structure to verify that this printing method can ensure the integrity of the structure.Printing spatial line structure to verify that this printing method can print multiple materials structure.Printing the capillary bifurcation structure to verify that this printing method can control the accurate deposition of material in space.Printing Y type vessel structure to verify that this printing method can be used to manufacture the internal flow path of the structure.