Clinical Study On The Treatment Of Bilateral Pheochromocytoma Caused By Multiple Endocrine Neoplasia Type 2

Objective:Multiple endocrine gland tumor type 2(MEN-2)is an autosomal-dominant-genetic disease,relatively rare,with less research and related literature.In this paper,I retrospectively analyzed 12 cases,with absolute clinical diagnosis of MEN-2,of the-past-20-year clinical treatments of urology department.In order to further understand,diagnose and cure this rare disease,as well as provide reference and the clinical basis for improving the prognosis of patients,we analyzed and compared the family genetic characteristics and prognosis of the disease.Materials and Methods:The clinical data of 12 patients with MEN-2 admitted to the Department of Urology of Shandong Provincial Hospital from May 1996 to December 2016 were analyzed retrospectively.Embarked on objective analysis of its clinical manifestation,imaging diagnosis,treatment and prognosis to further explore and assist in making the diagnosis and clearing surgical treatment principle.Results:According to 12-patients clinical cases,all patients had accepted abdominal CT examination in the hospital,imaging in the diagnosis of bilateral adrenal placeholder.Cases of 6 patients had been diagnosed as thyroid carcinoma with curative resection.5 cases were also found thyroid neoplasm and bilateral adrenal placeholder at the same time.One patient did not check thyroid ultrasound in the first hospitalization,thyroid neoplasm had been boserved in the half-year review after the resection of bilateral pheochromocytoma.A total of 5 patients had symptoms of oversecretion of catecholamine,tumor diameter of bilateral adrenal placeholder of seven of the patients were more than 6 cm,3 cases were family hereditary.(a family group).Conclusion:In daily clinical work,when encountering patients with high blood pressure,heart palpitations and other clinical symptoms,and radiographic examination revealing bilateral pheochromocytomas,thyroid ultrasound must be done to make it clear that whether the patients have got medullary thyroid carcinoma.Patients with these signs are highly suspected in suffering from multiple endocrine neoplasia.If conditions permit,RET gene diagnosis can be added to confirm.The current treatment is mainly surgery or preventive resection.when pheochromocytoma with other tumor existing at the same time,it should be first resection before others.