Relationship Between Serum Uric Acid And All-cause Mortality In Maintenance Hemodialysis Patients

Objective:To investigate the association between serum uric acid(SUA)and survival in maintenance hemodialysis patients(MHD).Methods:All included patients were from Zhejiang Dialysis Quality and Management Center(ZDQM),diagnosed with end stage renal disease,initiating MHD between Jan 1,2010 and Dec 31,2014,whose dialysis time were more than 3months.Cox proportional hazards regression was used to analyze the association between SUA and survival at three time points respectively,including the first dialysis,3 months after first dialysis and 12 months after first dialysis.Results:13270 patients were included in the present retrospective study.The median follow-up was 868(interquartile range,502-1375)days.2560 patients were dead and the mortality was 19.3%.SUA was negatively correlated to age and positively correlated to serum creatinine,blood urea nitrogen,albumin and phosphorus at all the three time points(P<0.05).When adjusted by COX multivariate regression model,an increase in SUA predicted lower mortality only appeared at 3 months after first dialysis(HR=0.99,P=0.03).Conclusion:Hyperuricemia may be a protective factors for MHD patients at 3 months after first dialysis,but still need to be proved by prospective study further more.