Clinical Observation Of Integrated Traditional Chinese And Western Medicine In The Treatment Of Severe Acute Pancreatitis

ObjectivesSevere acute pancreatitis(Severe Acute,Pancreatitis,SPA)is one of the common clinical acute abdomen,with acute onset,rapid progression,treatment for a long time,spend more,high mortality characteristics,early onset systemic inflammatory response syndrome(SIRS)and multiple organ dysfunction syndrome(MODS),a serious threat to human health.Even though its comprehensive treatment has made great progress so far,there is still a high mortality rate of 20%-30%.At present,the main method for the treatment of this disease is surgery,but the efficacy of surgical treatment is still controversial,and there is a certain risk of complications and recurrence.Continuous regional arterial infusion therapy helps reduce severe acute pancreatitis in patients with necrotizing pancreatitis and pancreatic infection rate and mortality,both at home and abroad started early continuous regional arterial infusion therapy in the treatment of severe acute pancreatitis,but due to technical and related professionals to carry out its limitation,the scope is limited,the effect is yet to be confirmed,but further the research,in order to develop a more standardized treatment.Traditional Chinese medicine has its unique advantages in treatment.In recent years,a large number of clinical studies confirmed that the obtained good clinical efficacy in treatment of severe acute pancreatitis with combination of TCM and Western medicine,the SPA clinical complications,operation rate and mortality rate were significantly decreased,the average hospitalization time,cost of hospitalization was significantly shortened.To observe the clinical effect of combined treatment of severe acute pancreatitis by traditional Chinese medicine and Western medicine,in order to better clinical application,to provide new ideas and new methods of clinical treatment and the mechanism and treatment of severe acute pancreatitis in traditional Chinese and Western medicine.MethodsIn this study,we retrospectively analyzed 42 patients in KangHua hospital from December 2011 to December 2016,according to the different treatment methods were divided into the control group(n = 22)and the treatment group(n = 20).The control group using conventional western medicine,treatment group in which the sampling continuous regional arterial infusion therapy combined with nasogastric tube houpupaiqi mixture treatment,compared two groups of the admission day,on the fifth day and tenth days of white blood cells,blood glucose,serum amylase,APACHE score,abdominal pain relief time,hospitalization days and total hospitalization expenses observation of the two groups.Results1?Two groups of patients with basic information,such as age,gender no significant difference.2?Comparison of two groups of patients with white blood cell count The white blood cell count of the treatment group on the day of admission,the fifth day of treatment,the treatment of the treatment for tenth days were respectively22.05±5.65(1X109/L)?14.47±2.14(1×109/L)?11.18±2.17(1×109/L);The control group on the day of admission,fifth days of treatment,the treatment of white blood cell counts for the tenth day were24.06±5.47(1×109/L)?17.32±3.70(1×10,/L)?13.10±2.41(1X109/L).Two groups of data comparison,the day of admission in the two groups of patients with white blood cell count was no significant difference(P>0.05),treatment for fifth days,the treatment group was lower than the control group,the white blood cell was statistically significant(P<0.05).3?Comparison of two groups of patients with blood glucoseOn the day of admission,the fifth day of treatment,the treatment of blood glucose for the first tenth days,respectively,was the value of 14.05±4.03(mmol/L)?8.53±2.08(mmol/L)?6.14±1.59(mmol/L);The control group on the day of admission,fifth days of treatment,the treatment of blood glucose for the first tenth days of the treatment were respectively at the rate of 13.51±4.09(mmol/L)?10.43±3.11(mmol/L)?7.29±1.59(mmol/L).Two groups of data comparison,the day of admission on the two groups of patients with no significant difference in blood glucose value(P>0.05),treatment for fifth days,the treatment group than the control group,the blood glucose level decreased significantly,with statistical significance(P<0.05).4?Comparison of serum amylase in two groupsOn the day of admission,the fifth day of treatment,the treatment of blood glucose for the first tenth days of treatment,the value of serum amylase was about 2409.75±1289.52(U/L)?471.60±262.23(U/L),and the value was 149.65 ± 58.71(U/L);The control group on the day of admission,fifth days of treatment,the treatment of blood amylase values for the first tenth days were2616.59±1448.82(U/L)?693.41±414.38(U/L)?194.50±58.09(U/L).The two groups of data comparison,the day of admission on the two groups of patients with no significant difference in serum amylase value(P>0.05),treatment for fifth days,the treatment group than the control group in the treatment of blood amylase value recovered quickly,with statistical significance(P<0.05).5?Comparison of APACHE-? score between the two groupsThe APACHE-? score of the treatment group on the day of admission,the fifth day of treatment,and the treatment for the first tenth days of treatment were37.05±5.06((points)),24.00±2.78(points)and8.50±1.82(points);The control group on the day of admission,fifth days of treatment,the treatment of for the second day of the score of APACHE-? was 37.27±5.0(points),4?26.41 ±3.31(points),10.86±2.40(points).Comparison of the two groups of data,the admission of the two groups of patients with APACHE-? score was no significant difference(P>0.05),treatment for fifth days,the treatment group than the control group APACHE-? score was lower,with statistical significance(P<0.05).6.Comparison of two groups of patients with abdominal pain relief time,total length of stay,hospitalization costsTreatment group abdominal pain relief time,the total length of stay,hospitalization costs were 4.45± 1.20(d),17.65 ±2.94(d),65296.30±255.03(yuan);The control group abdominal pain relief time,the total length of hospital stay,hospitalization costs were 5.50±0.86(d),22.36 ± 6.22(d),67152.59±538.38(yuan).Compared with the control group,the abdominal pain relief time,total hospitalization days and hospitalization expenses in the treatment group were lower than those in the control group(P<0.05).7?There were no serious complications such as severe cardiovascular,cerebrovascular and renal dysfunction in the two groups.ConclusionContinuous regional arterial infusion combined with houpupaiqi mixture in treatment of severe acute pancreatitis is superior to conventional western medicine alone,to promote patients with white blood cells,blood glucose,blood amylase,APACHE-? score,gastrointestinal function and so faster recovery,significantly improve clinical efficacy,and reduce hospital stay and hospital costs,Worthy of clinical promotion.