The Near Future Observations Of Chemoradiotherapy Combined With P53 Adenovirus Injection On Locally Advanced Cervical Cancer

Objective:To evaluate the recent clinical effects of chemoradiotherapy combined with recombinant human p53 adenovirus injection in the treatment of locally advanced cervical cancer.Methods :142 cases diagnosed with locally advanced cervical carcinoma were divided randomly into the treatment group(chemoradiotherapycombined with p53 gendicine injection)and the control group(chemoradiotherapy),with 42 cases in the former group and 100 cases in the other group.Recombinant human p53 adenovirus intratumor injection was performed once a week.Radiotherapy plan of two groups was in agreement.Two months after evaluation of curative effect.Meanwhile,before radiotherapy and after brush take cervical cells,DNA ploidy quantitative analysis,were compared between the two groups of patients with cervical cell DNA index(DI)is more than or equal to 2.5 cells.Results : In the treatment group,CR was in 26 patients(61.9%);PR 12patients(28.6%),and the effective rate was 90.5%;in the control group,CR was in28 patients(28%),PR 36 patient(36%),and the effectiverate was 64%.The effective rate of treatment group was higher than that of the control group(90.5% VS64.0%;P < 0.05).Analysis of DNA ploidy quantitative after chemoradiotherapy in treatment group and control group was statistically significant(χ2=6.558,P=0.01).Conclusion: Imaging and DNA ploidy quantitative analysis conclusion is consistent and showed that recombinant human adenovirus p53 combined with chemoradiotherapy in the treatment of advanced cervical cancer recent curative effect is better than chemoradiotherapy.