Relationship Among The Preoperative NLR,PLR And Clinicopathological Parameters And Prognosis In Patients With Esophageal Squamous Cell Carcinoma

Objective:To explore the correlation between preoperative NLR and PLR and clinicopathological features and postoperative prognosis of esophageal carcinoma,and to provide a new reference for clinical preoperative evaluation of staging and prognosis of esophageal cancer.Methods:Collected from January 2010 to January 2014 in our hospital esophageal cancer radical surgery in 101 patients,all patients were followed up for 18 months-30 months,and calculate the preoperative neutrophil and lymphocyte ratio(NLR)And platelet and lymphocyte ratio(PLR)were used to analyze the correlation between preoperative NLR and PLR and serum CEA,differentiation,TNM staging and prognosis in patients with esophageal cancer.Results:Kaplan-Meier analysis and logarithmic rank test showed significant differences in overall survival time(OS)between patients with NLR-PLR score of 0,1 and 2(P<0.001);multivariate analysis showed that OS and NLR-PLR(HR = 2.245,95%,CI:1.139-4.427),TNM staging(HR = 122.561,95%,CI:27.692-542.428).surgery ends with cancer cells(HR = 122.561,95%,CI:27.692-542.428),the middle of the lesion(HR = 19.581,95),the history of drinking(HR 3.998,95%.Cl:1.793-8.915)%,Cl:3.434-111.652),the lower thoracic segment(HR = 13.444,95%,CI:2.253-80.219.both P<0.001)were independently associated with OS.Conclusion:I.Preoperative NLR and PLR are associated with poor prognosis in EC patients and are a convenient,rapid and inexpensive predictor for predictive prognosis of EC.2.EC patients with sercrum CEA,history of drinking,duration of disease,tumor size,TNM staging,at the end of the tumor and the degree of differentiation associated with the OS.3.NLR.PLR score,TNM staging,drinking history,cut off the location of cancer cells and lesions are EC patients with independent prognostic factors.