The Preparation And Glucose Sensing Properties Of Nickel Oxide-based Nanocomposites Materials

Diabetes is a worldwide public health problem,thousands of people with diabetes need daily blood glucose testing,so glucose has become the most common analyte.Therefore,it is closely related to the diagnosis and treatment of diabetes with reliable and close blood glucose detection and control,which makes the detection of glucose has important clinical significance.Today,the application of non-enzymatic glucose sensor detection of glucose is still the focus of attention.Nanomaterials with unique properties can meet the non-enzymatic glucose sensor for the detection of simplicity,speed and other aspects of the requirements.Nanomaterials are widely used in the field of non enzymatic glucose sensor because of the continuous improvement of technology,the continuous improvement of the characterization methods and the integration with other subjects.In this paper,based on the review of the application of nanomaterials in non-enzymatic glucose sensors,the preparation of nickel oxide-based nanomaterials by hydrothermal method was systematically studied,including NiO/Ni/C microspheres,layered NiCo₂O₄ microspheres and NiCo₂O₄/C microspheres,and glucose sensing properties of the prepared nickel oxide-based nanostructure material was studied.The achieved results are as follows:?1?Ternary NiO/Ni/C microspheres was obtained by calcination of the precursor Ni?OH?2/C in pure nitrogen which was prepared via hydrothermal synthesis technology.The relationship between the morphology,phase composition and electrochemical properties of the ternary NiO/Ni/C microspheres were investigated.Results show that the NiO/Ni/C microspheres have a coral-like structure with diameter of about 1.7 ?m,and the crystalline phase of Ni and NiO are cubic.Compared with NiO/C,when the Ni / NiO molar ratio is 0.19,the ternary NiO/Ni/C microspheres have excellent glucose sensor performance with a sensitivity of 241.09?A·mM-1·cm-2 in range of 10 ?M⁵.05 mM,and a detecting limit of 10 ?M.Furthermore,the sensor has good stability and anti-interference ability.?2?The precursors of Ni and Co were prepared by hydrothermal method,and then the 3D-NiCo₂O₄ hierarchica microspheres were prepared by controlling the temperature during the calcination process.The 3D-NiCo₂O₄ hierarchical microspheres were used as the non-enzymatic glucose sensing materials.The 3D-NiCo₂O₄ hierarchical microspheres obtained at different calcination temperatures were analyzed and compared.It was found that the electrochemical activity of NiCo₂O₄ hierarchical microspheres prepared at 300? was the best.The results show that the as prepared 3D-NiCo₂O₄ microspheres are composed of closely connected outstretched nanowires with the average diameter about 50 nm and length about 1¹.5?m.The nanowires are actually made up of many nanoparticles with the diameters less than 10 nm.The amperometric responses are linear with glucose in the concentration range of 10¹0480 ?M,a sensitivity of 430.86?A·mM-1·cm-2.Compared with pure NiO microspheres,3DNiCo₂O₄ hierarchical microspheres exhibited higher current response to glucose and higher sensitivity,showing excellent electrochemical activity.?3?The precursor of Ni Co2O4 was prepared by hydrothermal method with carbon spheres as template,and the NiCo₂O₄/C microspheres were obtained by calcination.Scanning electron microscope?SEM?,X-ray diffraction?XRD?were used to characterize morphology and structure of the samples.Results show that the diameter of NiCo₂O₄/C microspheres is around 6.2 ?m,and the microspheres consist of nanowires with diameter of 50 nm.Electrochemical behavior and sensing property of the NiCo₂O₄/C microspheres were studied via cyclic voltammetry and amperometric method.The results displayed that the NiCo₂O₄/C microspheres have good electrochemical activity,its sensitivity is 544.75?A·mM-1·cm-2,linear response range is 10⁸620?M.