| ObjectiveThe aim of the study was to compare the clinical and radiology parameters of oral implant restorations in well-controlled type 2 diabetes mellitus(T2DM)and healthy patients retrospectively and to evaluate the influence of type 2 diabetes mellitus,which provide theoretical basis for the oral implant restorations in type 2 diabetes mellitus.MethodsThe retrospective clinical study evaluated partially posterior edentulous patients from Department of Implantology,School of Stomatology of Zhengzhou University during January 2011 to January 2015.All of the patients were followed up at least for two years.56 patients with 123 implants were included,23 T2 DM patients with 52 implants(11 female patients and 12 male patients,mean age: 57.48±7.34 years)as a T2 DM group and 33 healthy individuals with 71 implants(16 female patients and 17 male patients,mean age: 54.12±7.81 years)as a control group.HbA1c test confirmed that the glycemic control of T2 DM patients was well(HbA1c range: 6.0%~8.0%).In all cases,Straumann tissue implants were inserted at sites that had undergone at least 3 months healing after dental extraction.After 3~6 months of healing period,the final prostheses were installed.The parameters that were evaluated were wound-healing parameter at 10 th postoperative day,implant stability quotient(ISQ)when making the impression,cumulative survival rate(CSR),peri-implant soft tissue parameters and peri-implant marginal bone loss(MBL)at 6,12 and 24 months following prostheses placement.MBL and the peri-implant soft tissue parameters as follows: modified plaque index(mPLI),bleeding on probing(BOP),probing depth(PD),were selected to assess the general state of patients' peri-implant health or diseases.Clinical and radiology parameters of two study groups and of different follow-up time were compared.The influence of jaw of treatment,the reason for tooth loss and advanced surgery were assessed.Spearman's correlation between HbA1 c and mPLI?BOP?PD?MBL were analysed.Statistical significance was established as P< 0.05.ResultsSubjects with well-controlled type 2 diabetes mellitus may not be significantly compromised and can have similar clinical effect compared to healthy individuals during two years follow-up.(1)clinical parameters including wound-healing parameter,ISQ,mPLI,BOP and PD were not statictically different between two groups(P>0.05);mPLI,BOP and PD did not change significantly with time(P>0.05);(2)radiology parameter MBL in T2 DM patients ranged from 0.47 mm after 6 months to 0.78 mm after 2 years incomparison with respective values of 0.43 mm and 0.71 mm in healthy patients,T2 DM patients exhibited higher MBL(P<0.05);MBL increase significantly with time(P<0.05);(3)in addition to that individuals with periodontitis-associated tooth loss exhibited higher MBL,clinical and radiology parameters were not significantly different for jaw of treatment,the reason for tooth loss and advanced surgery;(4)Spearman's correlation between HbA1 c and mPLI?BOP?PD?MBL were analysed and did not reach statistical significance;(5)during the two years follow-up,CSR of two study groups were both 100%;(6)the prevalence of peri-implant mucositis and peri-implantitis were not statistically different in well-controlled T2 DM patients and healthy patients at the patient and implant level(P>0.05).ConclusionWith the limitation of the retrospective clinical study,T2 DM patients can receive implant treatments safely,providing well-controlled glycemia over time assessed by monitoring HbA1 c levels.Cumulative survival rate,healing and health condition of peri-implant soft and hard tissue in people with or without T2 DM did not differ significantly.The difference in marginal bone loss between people with T2 DM and people without T2 DM may be statistically,but not clinically,singificant.In individuals with periodontitis-associated tooth loss,peri-implant marginal bone loss may increase significantly. |
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