Recent Therapeutic Observation And Complication Analysis Of Brachytherapy Implantation In Local Intermediate And Advanced Cervical Cancer

Aims:To evaluate the recent therapeutic effect and complication analysis of of brachytherapy implantation in local intermediate and advanced cervical cancer.Methods and materials:Choose 48 cases locally Intermediate and advanced cervical cancer from our hospital with February 2015 to January 2016,both by pelvic enhancement MRI and colposcopy biopsy pathology confirmed.Age 33 ~74,the average age was 55.4±8.25,the median age was 54.According to the 2009 cervical FIGO staging criteria,?A1 stage 1 case,?A2 stage1 case,IIB stage 26 cases,IIIA stage 6 cases,IIIB stage 13 cases,IVA stage 1 case.Treatment plan including pelvic radiation graft and synchronization between external exposure,organization sensitization of chemotherapy.Pelvic external exposure dose 50.4 Gy,single dose limit of1.8 Gy,abdominal aorta branch into positive pelvic lymph node synchronization added amount to 60-66 Gy.Sensitization chemotherapy once a week,30 mg/m2.Pelvic external exposure end inserted between cervical tissue plant after radiotherapy.Implementation of bladder indwelling catheter before operation,500 ml warm soapy water cleaning enema,rectal tube flag when planting,urine tube injection of saline solution containing compound meglumine generic shade 50 ml full bladder.Performer according to the specific size of the tumor and invasion and scale operation,the plant steel needleResults:Among 48 cases,33 patients(68.7%)achieved complete remission,and seven patients(14.6%)achieved some relief,treatment efficiency can reach 83.3%.Five patients died,of which 1 case died late stage IIB patients with uremia.1 patients with IVA period because of the cervical area local recurrence and death.In addition to the stage IIB,IVA,the rest of the various stages in the survival rates were above 90%.? A period in the study,patients with stage IIIA 1-year progression-free survival rate was 100%,of patients with stage IIB 1 years progression-free survival rate was 88.0%,and the patients with stage IIIB progression-free survival rate of 84.6% A year.A total of 6 patients with recurrence or metastasis.28 patients(58.3%)in grade 1 to grade 3 acute radiation proctopathy,25patients(52.1%)in grade 1 to grade 3 acute radiocystitis,no patients with severe acute radiation injury.With nine patients(18.8%)in 1-2 levels of chronic radiation proctopathy,11 patients(22.9%)in 1-2 levels of chronic radiation cystitis,no patients with severe chronic radiation injury.Conclusion:Interstitial radiation graft short-term curative effect,significantly improve the complete remission rate,partial remission rate,and improves the survival rate of 1 year and progression-free lifetime.Organization between the side reaction of radiation graft,significantly reduce the probability of the acute and chronic severe radiation damage,has the very good treatment feasibility of relatively safe and reliable.