| Objective:Meta-analytic method was used to analyze related studies in order to get a clear result of whether or not the saccadic changes in patients with Parkinson’s disease,especially in reaction time,average peak velocity,accuracy and error rate,comparing to the normal control group is existed.And we hope to find out whether it means something for differential diagnosis of Parkinson’s disease.We hope that the study will guide the researches in the future.Methods:We have searched for related studies in visually guided horizontal saccades in 4databases including Medline,Embase,Chinese National Knowledge Infrastructure and China Biology Medicine disc since 1972.1 updated to 2017.2,and add some studies from other methods.In this section,we selected researches meeting the standard according to the inclusion and exclusion criteria we established before,and used them in meta-analysis.Then we got the data we needed and did quality assessment and data pooling with it.When we did meta-analysis,we study the factors including saccadic reaction time,average peak velocity and accuracy which is in the form of standardized mean difference(SMD),and the error rate which is in the form of odds ratio(OR).Results:After searching databases we got 27 control studies,including 583 patients and490 healthy subjects.In step paradigm,saccadic reaction time in patients with Parkinson’s disease is significantly higher than in healthy subjects,and the difference is statistically significant.From cumulative meta-analytic method,weproved that the results has been stable since 1989.And the Begg’s method and sensitivity analysis showed that the publication bias is not statistically significant.When the scanning angle is greater than or equal to 25 degrees,patients with Parkinson’s disease got less average peak velocity than control subjects,and the difference is statistically significant.And the publication bias is not statistically significant too,according to the Begg’s method and sensitivity analysis showed that.However,there was no significant difference in saccade accuracy and saccade error rate between the patients and the control group.Conclusions:1.Patients with Parkinson’s disease have prolonged response time in visually guided horizontal saccades;2.When the saccade eccentricity is greater than(or equal to)25 degrees,the average peak velocity of visually guided horizontal saccades is reduce in patients with Parkinson disease decreases;3.Patients of Parkinson’s disease with visual induced horizontal saccadic have prolonged reaction time and reduced the peak velocity,which is not completely related dementia. |
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