The Value Of DCE-MRI Quantitative Parameters In High Intensity Focused Ultrasound(HIFU) Ablation's Immediate Effect For Uterine Fibroids

Objective:To evaluate the immediate value of dynamic contrast-enhanced MRI?DCE-MRI?quantitative parameters after HIFU treatment of uterine fibroids by studying the correlation between the quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging?DCE-MRI?and the therapeutic effect of uterine leiomyoma.Materials and Methods:According to the inclusion and exclusion criteria,13 cases of uterine fibroids by HIFU were treated with Philips Achieva 3.0T magnetic resonance imaging.MRI routine scan and DCE-MRI examination were performed within 1 days before treatment and after treatment for 1 days.Omni-Kinetics?GE Healthcare?software was used to obtain the quantitative parameter values according to the dual chamber Tofts model.They were grouped into two groups,the complete ablation group and the non-complete ablation group according to appearance of DCE-MRI.Quantitative DCE-MRI parameters and their changes before and after treatment were assessed and compared.Mann-Whitney U test and analysis of variance were compared between the two groups.Spearman,scorrelations were applied to find the association between quantitative parameters and groupings.Results:1.DCE-MRI parameters?Ktrans,Kep,Ve?were significantly lower after HIFU ablation?p<0.05?,Vp change is not obvious;2.In addition to Vp_{before treatment-after treatment},all quantitative parameters before treatment subtract the quantitative parameters after treatment?i.e.,before treatment-after treatment?were not associated with group?P > 0.05?;3.Ktrans_{after treatment},Ve_{after treatment}and Ktrans_{rate of change},Ve_{rate of change}were correlated with group.Ktrans_{after treatment}and Ve_{after treatment}were positively correlated with the grouping,and correlation coefficents were0.713 and 0.757 respectively.Ktrans_{changeable rate}and Ve_{changeable rate}were negatively correlated with the grouping,and correlation coefficients both were-0.802,and the correlation is more significant.Conclusion:DCE-MRI quantitative parameters can be used to evaluate the immediate efficacy by HIFU treatment of uterine fibroids,and it has reference value for the guidance of clinical prognosis.