| Objective:To compare the clinical and pathological characteristics of young and elderly patients with gastric cancer,and to study the differences and common points between young gastric cancer and elderly gastric cancer,and to provide the theoretical basis for the prevention and treatment of gastric cancer.Materials and methods:To compare the gender,clinical symptoms,family history,tumor markers(CEA),tumor location,the microscopic type,organization credit type,tumor stage and surgical treatment of young and elderly patients with gastric cancer.Retrospectiving analysis the clinical data of 112 patients with gastric cancer who admitted to China-Japan Union Hospital of Jilin University from January 2006 to December 2015.They were diagnosed by pathology or postoperative pathology,accompanied by other primary malignant tumors were not included in the study.We defined ≤ 30 years old as young group,≥ 70 years old defined as the elderly group,including 42 cases of young patients,elderly patients 70 cases.Data were analyzed by SPSS21.0 statistical software,the difference between the use of X~2 test,P <0.05 for the difference wasstatistically significant.Results:(1)Gender: young women with gastric cancer were more common than men,male to female ratio: 1: 1.3,women accounts for 57.14%;elderly group of gastric cancer is predominant male,male to female ratio:2.33: 1,male accounts for 70%,two groups of comparative difference has significant statistical significance(P <0.05).(2)Clinical symptoms: abdominal pain is the main clinical symptom in the patients of youth group(57.14%)and the elderly group(80%),the differences of comparative between two groups have significant statistical significance(P <0.05);Hematemesis and melena in the youth group(33.33%)are more common than the elderly group(17.14%),two groups of comparative differences have significant statistical significance(P <0.05);Difficulty swallowing,the posterior discomfort and the wasting symptoms in the elderly group are more common than the youth group,and the differences were statistically significant(P<0.05);Anemia,loss of appetite,abdominal mass symptoms are more common than the youth group,the differences of comparative between two groups have no significant statistical significance(P> 0.05).(3)Family history: The youth group of family history accounts for19.05%,2.86% of the elderly group,two groups of comparative differences have significant statistical significance(P <0.05).(4)Tumor markers:The percentage of CEA in the positive in the youth group is 14.29%,and that of the elderly group is 17.14%,and there is no significant differences between the two groups(P> 0.05).(5)Tumor location: The general location of gastric cancer of the youth group is gastric antrum,the youth group accounts for 61.90%,the elderly group accounts for 34.29%,two groups of comparative differences have significant statistical significance(P <0.05);The incidence of gastric body in the youth group is slightly lower than that in the elderly group,the difference have no statistically significant(P>0.05);The incidence of gastric cardia in the youth group is 9.52%,which is lower than that in the elderly group(37.14%),the difference between two groups is statistically significant(P <0.05);The incidence of widespread carcinoma in the youth group is higher than that in the elderly group,there is no significant difference between two groups(P> 0.05).(6)The microscopic type:Borrmann Ⅲ and Borrmann Ⅳ gastric cancer are taken primarily in the youth group,the elderly group is mainly Borrmann II and Borrmann Ⅲ.Borrmann Ⅳ type accounts for 33.33% of the youth group and 17.14% in the elderly group,The difference between the two groups is statistically significant(P <0.05).Borrmann I type in the youth group(4.76%)is lower than that of the old one(18.57%),the difference between two groups is statistically significant(P <0.05).Both Borrmann II and Borrmann Ⅲ are no statistically significant in two groups.(P> 0.05).(7)Organization credit type: The poorly differentiated adenocarcinoma and signet ring cell cancer in the youth group account for 42.86%,16.67%,the elderly group accounts for 17.14%,4.29%,the differences between two groups are statistically significant(P <0.05).The well differentiated adenocarcinoma and the moderately differentiated adenocarcinoman in the youth group accounts for 4.76% 、 9.52%,the elderly group accounts for 8.57%,34.29%,the differences between two groups are statistically significant(P <0.05).The mucinous adenocarcinoma,the undifferentiated carcinoma and the stomach extensively cancer are no statistically significant in two groups(P> 0.05).(8)Tumor stage: Ⅲ period and Ⅳ period are taken primarily in the youth group,the elderly group is mainly II,Ⅲ and Ⅳ period.Ⅳ period in the youth group(45.24%)is higher than the elderly one(25.71%),The difference between two groups is statistically significant(P <0.05).II period in the youth group(9.52%)is lower than that of the old one(25.71%),the difference between two groups is no statistically significant(P>0.05).(9)Surgical treatment:The surgical operation rates of the youth group and the elderly group account for 76.19% and 80%,two groups of comparative difference has no significant statistical significance(P>0.05).The youth group’s radical surgery rate(47.62%)is more obviously lowerthan the elderly one(67.14%),the youth group’s radical surgery rate(28.57%)is higher than the elderly one(12.86%),the differences between two groups are statistically significant(P <0.05).Conclusion:1.Female is more common than male in the youth group,male is more common than female in the elderly group,the youth patients with gastric cancer have more family history.2.The general location of gastric cancer of the youth group is gastric antrum,clinical stage is later,gastrointestinal bleeding is the main performance in youth group;Gastric cardia cancer is main of the elderly,digestive dysfunction is the main performance in the elderly.3.Compared with the elderly gastric cancer,the youth patients with poor pathological type,late stage and the proportion of radical surgery is low. |
