The Diagonosis Value About The Prostate Cancer In The Clinical Research Of PSA Correlation Designated Object And The Prostate Gland Puncture Needle Number And The Position Spot

Objective:To investigate the clinical diagnostic value of f/tPSA?PSAD and(f/t)PSA/PSAD,and different needle number and locations for the result of the biopsy in the patients(PSA 4 ~ 10 ng/ml).Methods:A total of 929 cases were submitted TURS-guided prostate biopsy in our hospital from January 2008 to March 2016,of which the clinical data of 249 cases with PSA 4~10ng/ml were analyzed.According to the pathology results,the patients divided into prostate cancer group(PCa group)38 cases(15.26%),benign prostatic hyperplasia group(BPH group)211 cases(84.74%).The patient age,tPSA,f/tPSA,prostate volume,PSAD,(f/t)PSA/PSAD were statistically analyzed.According to the prostate biopsy needle number and site groups: group A,the puncture needle 13,A total of 218 cases;Group B,13 + n needle biopsy,a total of 31 cases.Statistical significance for two groups of patients under different number of needle puncture positive difference were compared.Results:According to the number of patients with prostate biopsy needles and site group,218 cases of group A pathology report for carcinoma is 27 cases,puncture positive rate were 12.39%;group B of 31 cases of pathological report for carcinoma in 11 cases,puncture positive rate were 35.48%.According to the chi-square test,increase the needle number and the site after a positive rate increase was statistically significant(?~2= 9.48,P<0.005).There is no statistically difference between the two groups on the mean value of age level(P>0.05).The mean value of f/tPSA?prostate volume?(f/t)PSA/PSAD level,BPH group were issignificant higher than the PCa group;The mean value of tPSA ? PSAD level,the PCa group were significant higher than the BPH group(all P<0.05).32 cases with F/tPSA or PSAD abnormal were detected in the PCa group(84.21%);110 cases with f/tPSA or PSAD abnormal were detected in BPH group(52.13%);and there is a statistically significant difference(?~2=13.52,P<0.005).Conclusion:Lower PSA(tPSA 4~10ng/ml)of the patients,for patients with early tumor lesions is small,we shoud increase needle number and the site as soon as possible(including saturated puncture),to reduce the missed diagnosis as much as possible.f/t PSA and PSAD for patients with PSA(tPSA4~10ng/ml)have a significant guiding value.If f/t PSA and PSAD results is contradict,the diagnostic value of f/tPSA joint PSAD ? PSAD joint(f/t)PSA/PSAD are relatively high.