Pressure Combined High-fatdiet Effects On Atheroscierosis And The Intervention Of The "Yue Ju Pills"

ObjectiveIn order to observe the pressure on the mice serum inflammatory reaction and the influence of the stability of atherosclerotic plaques,from the Angle of inflammation to investigate the stress in the development of atherosclerosis role,and using the "Yue ju pills" to intervence,observed in the stress of Chinese medicine cause at hero sclerosis occurs in the intervention effect.methodsExperiment through giving different stress to establish the animal model of chronic stress,48 apoe-mice were randomly divided into 6 groups,blank group,model group,high dose of Chinese medicine + atorvastatin calcium tablets,middle dose of Chinese medicine + atorvastatin calcium tablets,low dose of Chinese medicine + atorvastatin calcium tablets,atorvastatin calcium tablets group.Six groups to a high-fat diet,except the blank group groups randomly assigned stress experiment lasted 12 weeks,the experimental treatment from the start,12 weeks after blood check E select element,hs-CRP,take the aorta immunohistochemical method is used to analyze neuropeptide Y,E element,lipoprotein phospholipase A2 expression differences in mice aorta and aortic plaque vulnerability index calculation.Setting up a set of normal eight C57B1/6 male mice,normal diet,no stress test,no drug therapy.ResultsAfter 12 weeks stress experiment,the mice,s hscpr and E element are increasing,marked the inflammatory reaction,and at the same time in the aorta to the "Yue ju pills" after the intervention,E select element,the expression of neuropeptide Y and lipoprotein phospholipase A2 increased the content of inflammatory markers to drop,the curative effect of the "Yue ju pills"dose effect only reflect in E select element.At the same time to vulnerability index evaluation,the occurrence of inflammation and negatively correlated with the stability of the plaques.ConclusionStress can increase the risk of coronary heart disease incidence,can be used as a risk factor for coronary heart disease(CHD).Under the pressure of rat serum in mice,increased levels of hsCRP,E-select element indicates that chronic stress can lead to inflammation;Pathology tests also show that in the aorta in mice after chronic stress stimulation E select element,an increase in the expression of neuropeptide Y and lipoprotein phospholipase A2,and vulnerability index evaluation,inflammation,and negatively correlated with the stability of the plaques;To the "Yue ju pills" after the intervention,the content of inflammatory markers,provides strong evidence from depression treatment for coronary heart disease.